Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction

摘要

many chronic kidney diseases, regardless of the nature or the initial injury, progress to end-stage renal disease (ESRD) with irreversible loss of tissue and function. Tubulointerstitial fibrosis is a hallmark of chronic progressive kidney disease and is thought to be the final common mechanism that leads to ESRD (14). The pathogenesis of tubulointerstitial fibrosis is characterized by relentless production and deposition of extracellular matrix (ECM) proteins, such as fibronectin and collagens within the interstitium of the kidney, and strongly correlates with deterioration of renal function (19). A better understanding of the nature of chronic kidney disease leading to prevention and effective therapy is critical, such as strategies that suppress elaboration of ECM and thereby inhibiting the pathogenesis of tubulointerstitial fibrosis and prevent development of ESRD