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首页> 外文期刊>Chemistry of Materials: A Publication of the American Chemistry Society >Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity
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Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity

机译：纳米粒子表面功能决定了细胞和系统性毒性

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摘要

Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.
机译：近年来，工程纳米颗粒（NPS）在治疗剂和诊断中开辟了新的前沿。 The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. 在本综述中，我们将专注于各种亚细胞过程对蜂窝摄取和NPS运输的表面功能的影响。

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    Amir Ata Saei; Mahdieh Yazdani; Samuel E. Lohse; Zahra Bakhtiary; Vahid Serpooshan; Mahdi Ghavami; Mahtab Asadian; Samaneh Mashaghi; Erik C. Dreaden; Alireza Mashaghi; Morteza Mahmoudi;

  • 作者单位

    Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm 171 77 Sweden;

    Department of Chemistry University of Massachusetts Amherst Amherst Massachusetts 01003 United States;

    Physical and Environment Sciences Program Colorado Mesa University Grand Junction Colorado 81501 United States;

    Research Center for Pharmaceutical Nanotechnology Faculty of Pharmacy Tabriz University of Medical Sciences Tabriz 5166/15731 Iran;

    Stanford Cardiovascular Institute Stanford University School of Medicine Stanford California 94305 United States;

    Department of Cellular and Molecular Medicine Faculty of Health Sciences University of Copenhagen Copenhagen 1165 Denmark;

    Faculty of Engineering &

    Architecture Department of Applied Physics Research Unit Plasma Technology (RUPT) Ghent University Ghent 9000 Belgium;

    School of Engineering and Applied Sciences and Department of Physics Harvard University 29 Oxford Street Cambridge Massachusetts 02138 United States;

    Koch Institute for Integrative Cancer Research Department of Chemical Engineering Massachusetts Institute of Technology Cambridge Massachusetts 02139 United States;

    Leiden Academic Centre for Drug Research Faculty of Mathematics and Natural Sciences Leiden University Leiden 2311 EZ The Netherlands;

    Department of Anesthesiology Brigham and Women’s Hospital Harvard Medical School Boston Massachusetts 02115 United States;

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  • 正文语种 eng
  • 中图分类 工程材料学;
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