Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats

Xin Jihua; Zhang Yan; He Zhenzhou; Wang Zhenhong

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Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats

机译：高度选择性非阿片类κ表型受体（Kor）激动剂Salvinorin A保护患者血液损伤的大鼠脑损伤

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Objective: To investigate the effect of salvinorin A (SA) on brain injury and neurologic function post-brain ischemia/reperfusion (I/R) using a rat forebrain ischemia model and further explore the effect of kappa opioid receptor (KOR) inhibition by SA on aquaporin-4 (AQP4) expression in the hippocampus, cortex and striatum in the forebrain.

机译：目的：探讨Salvinorin A（SA）对脑损伤和神经系统功能后脑缺血/再灌注（I / R）的影响，使用大鼠前脑缺血模型，进一步探索καapioid受体（KOR）抑制的影响在海马，皮质和前脑中的纹状体中的Aquaporin-4（AQP4）表达。

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《Brain research》 |2016年第null期|共9页
作者
Xin Jihua; Zhang Yan; He Zhenzhou; Wang Zhenhong;
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作者单位

Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Dept Anesthesiol South Campus 2000 Jiangyue Rd;

Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Dept Anesthesiol South Campus 2000 Jiangyue Rd;

Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Dept Anesthesiol South Campus 2000 Jiangyue Rd;

Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Dept Anesthesiol South Campus 2000 Jiangyue Rd;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
Aquaporin-4 (AQP4); Cerebral edema; Ischemia/reperfusion; Kappa opioid agonist; Salvinorin A; Motor function; Cognition;

机译：Aquaporin-4（AQP4）;脑水肿;缺血/再灌注;κAphioid激动剂;Salvinorin A;运动功能;认知;

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1. Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats [J] . Xin Jihua, Zhang Yan, He Zhenzhou, Brain research . 2016,第Null期

机译：高度选择性非阿片类κ表型受体（Kor）激动剂Salvinorin A保护患者血液损伤的大鼠脑损伤
2. Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats [J] . Xin Jihua, Zhang Yan, He Zhenzhou, Brain research . 2016,第Null期

机译：高度选择性的非阿片类药物阿片受体（KOR）激动剂Salvinorin A可预防大鼠前脑缺血性脑损伤
3. Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats [J] . Xin Jihua, Zhang Yan, He Zhenzhou, Brain research . 2016,第Null期

机译：高度选择性的非阿片类药物阿片受体（KOR）激动剂Salvinorin A可预防大鼠前脑缺血性脑损伤
4. Detection of the Kappa Opioid Receptor (KOR) Antagonists in Mouse Brain Using LC-MS/MS Weeks After Administration. [C] . Kshitij A. Patkar, Nicolette C. Ross, Michelle L. Ganno, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用LC-MS / MS在给药后的LC-MS / MS在小鼠脑中检测Kappa阿片类受体（Kor）拮抗剂。
5. Non-opioid mechanisms of kappa agonists: Inhibition of stimulated phosphoinositide hydrolysis. [D] . Duan, Naili. 1996

机译：κ激动剂的非阿片类药物机制：抑制刺激的磷酸肌醇水解。
6. Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway [O] . Li-jie Liu, Jian-jun Yu, Xiao-lin Xu 2018

机译：κ阿片受体激动剂U50448H通过激活PI3K / Akt信号通路保护大鼠免受肾脏缺血再灌注损伤
7. Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway [O] . Li-jie Liu, Jian-jun Yu, Xiao-lin Xu 2017

机译：Kappa-Apioid受体激动剂U50448H通过激活PI3K / AKT信号通路来保护大鼠肾缺血再灌注损伤

Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats

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