Transient proliferation of donor-derived ATL cell-like lymphocytes early after allogeneic stem cell transplantation in an adult T-cell leukemia/lymphoma patient.

摘要

A 46-year-old man was admitted to our hospital because of systemic lymphadenopathy and generalized erythema. White blood cell (WBC) count was 8.3 X 109/L with 8% morphologically abnormal lymphocytes that were positive for CD3, CD4, and CD25. Antibody against human T-cell lymphotropic virus type I (HTLV-1)was positive, and Southern blot analysis (SBA) using his peripheral blood (PB) and a biopsy specimen of erythema revealed monoclonal integration of HTLV-1 pro virus. With an elevated serum lactate dehydrogenase level (642 IU/L), he was diagnosed as having acute-type adult T-cell leukemia/lymphoma (ATL).