Protamine-induced thrombocytopenia?

摘要

Protamines are small, positively charged, DNA-binding proteins found in the sperm of invertebrate and vertebrate animals. Protamine sulfate, derived from salmon sperm, is used to reverse the anticoagulant activity of unfractionated heparin during CPB and as a stabilizer in neutral protamine Hagedorn (NPH), a long-acting formulation of insulin.