首页> 外文期刊>BioMed research international >The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type
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The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type

机译:6Q21和PRDM1的遗传缺失及鼻窦淋巴瘤,鼻腔中的临床意义

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摘要

6q21 genetic deletion has been frequently detected in extranodal NK/T cell lymphoma, nasal type (EN-NK/T-NT), and PRDM1 is considered as candidate gene. However, direct detection of PRDM1 deletion has not been well documented. We investigated genetic alterations of 6q21 and PRDM1 in 43 cases of EN-NK/T-NT and cell lines by FISH. PRDM1 expression was evaluated by immunohistochemistry and Western blot. The correlation between genetic alteration and PRDM1 expression and the significance in clinic-pathologic were analyzed. Heterozygous deletion of 6q21 and/or PKDM1 was observed in 24 of 43 cases (55.81%) of EN-NK/T-NT including 16 cases (37.21%) for 6q21 deletion and 19 cases (44.19%) for PRDM1 deletion. Similarly, heterozygous codeletion of 6q21 and PRDM1 was identified in NK92 and NKL cells. The heterozygous deletion of 6q21 and/or PRDM1 was correlated with PRDM1 expression. However, genetic deletion of 6q21 and/or PRDM1 was not correlated with clinicopathological features of EN-NK/T-NT, while PRDM1 expression showed positive effect on the outcome of patients as those as disease site, B symptom, and clinical stage. Thus, heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in EN-NK/T-NT and correlated with downregulation of PRDM1. But the prognostic role of genetic deletion needs to be further evaluated in larger cohort.
机译:6Q21遗传缺失经常检测在外骨NK / T细胞淋巴瘤中,鼻型(EN-NK / T-NT)和PRDM1被认为是候选基因。但是,PRDM1删除的直接检测并未被充分记录。我们通过鱼的43例en-NK / T-NT和细胞系调查了6Q21和PRDM1的遗传改变。 PRDM1表达通过免疫组织化学和Western印迹进行评估。分析了遗传改变与PRDM1表达与临床病理学意义的相关性。在43例(55.81%)的en-NK / T-NT中,在第23例(55.81%)的含量为6℃(37.21%)的杂合缺失,包括16例(37.21%),缺失19例(44.19%)。类似地,在NK92和NKL细胞中鉴定了6Q21和PRDM1的杂合性复杂性。 6Q21和/或PRDM1的杂合缺失与PRDM1表达相关。然而,6Q21和/或PRDM1的遗传缺失与EN-NK / T-NT的临床病理特征无关,而PRDM1表达对患者的结果显示为疾病部位,B症状和临床阶段的结果。因此,杂合缺失6Q21和/或PRDM1经常在en-NK / T-NT中检测,并与PRDM1的下调相关。但是需要在较大的队列中进一步评估遗传缺失的预后作用。

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