Dermal closing is the route of administration in which a test substance is applied to an area of an animal's skin usually a rat's back, for a given amount of time in order to replicate the intended clinical route in humans or animals or it is the expected route for the exposure of chemicals. This is usually performed employing the 'semi-occluded' method covering of the test site whilst still allowing the skin to breathe - as outlined in this poster.
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