Isoxazole-containing neonicotinoids: Design, synthesis, and insecticidal evaluation

摘要

A series of novel isoxazole-containing neonicotinoids were synthesized from nitromethylene analogues and aromatic aldehydes in the presence of L-proline/K2CO3. Bioassays indicated that several synthesized compounds showed 40-70% mortality against brown planthopper (Nilaparvata lugens) under the concentration of 4 mg L-1, higher than that of imidacloprid (20%). Against cowpea aphid (Aphis craccivora), the best activity of title compounds reached 90% at the concentration of 20 mg L-1. (C) 2017 Published by Elsevier Ltd.