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首页> 外文期刊>American Journal of Epidemiology >Petersen et al. Respond to 'Effect modification by time-varying covariates'
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Petersen et al. Respond to 'Effect modification by time-varying covariates'

机译:彼得森等。响应“时变协变量的效果修改”

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摘要

We thank Robins et al. (1) for their thoughtful commentary on our article (2). Before responding, we wish to point out that they altered our notation slightly, using m rather than j to refer to the baseline time point.Robins et al. distinguish between two types of history-adjusted marginal structural models (HA-MSMs), those that consider an outcome at a fixed time point ("group 1," or those with multiple baseline time points for a single time-point-specific outcome) and those that consider a moving outcome ("group 2," or those that still use multiple baseline time points but use no more than a single baseline for each time-point-specific outcome). They raise the issue of model incompatibility and make the point that "only MSMs in group 1 can be incompatible and thus lead to logical inconsistencies" (1, p. 996). We concur with their discussion of the pitfalls that can be involved in modeling group 1 HA-MSMs and appreciate their emphasis on this issue
机译:我们感谢罗宾斯等。 (1)对我们的文章(2)进行了周到的评论。在做出响应之前,我们希望指出,他们使用m而不是j来表示基准时间点,从而对我们的表示法做了些微改动。区分两种类型的历史调整边际结构模型(HA-MSM),即在固定时间点考虑结果的模型(“第1组”,或针对单个时间点特定结果具有多个基准时间点的模型)以及考虑到动态结果的用户(“第2组”,或仍使用多个基准时间点但每个特定时间点的结果只使用一个基准的用户)。他们提出了模型不兼容的问题,并指出“只有第1组中的MSM才可能不兼容,从而导致逻辑上的不一致”(1,第996页)。我们同意他们对第1组HA-MSM建模可能涉及的陷阱的讨论,并赞赏他们对这一问题的重视

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