Effect of Psyllium Husk on the Suppression of Postprandial Elevation of Serum Triglyceride Level in Human —A Randomized, Double-blinded, Placebo-controlled, Crossover Study—

摘要

Objectives This study aimed to investigate the effects of psyllium husk ingestion on the suppression of postprandial serum triglyceride elevation in healthy adults. Methods A randomized, double-blinded, placebo-controlled, crossover study was conducted. A total of 80 subjects ingested psyllium husk or placebo (without psyllium husk) and consumed 180 g of hamburger, two butter rolls, and 30 g of shoestring potatoes as a high-fat meals load (total fat: 43.2 g)15 min after ingestion. Blood samples were collected before meals and 2, 3, 4, and 6 h after meals to measure serum triglyceride and remnant-like particle cholesterol (RLP-cholesterol) levels. Results Psyllium husk ingestion significantly suppressed the change in serum triglyceride levels at 2 and 3 h postprandially than after placebo ingestion (2 h, P<0.001;3 h, Pく0.05)and the incremental area under the curve from 0 to 6 h postprandially (iAUC0-6h) than after placebo ingestion (iAUC0-6h, Fく 0.05). In addition, psylhum husk ingestion significantly suppressed the change in RLP-cholesterol levels at 3 and 4 h postprandially (P < 0.05), and the iAUC0-6h was also significantly lower than after placebo ingestion (P<0.01). Conclusions These results confirm that psyllium husk ingestion suppresses the postprandial elevation of serum triglyceride and RLP-cholesterol levels.(UMIN000035337)