首页> 外文期刊>American Journal of Epidemiology >Sex differences in subclinical atherosclerosis by race/ethnicity in the multi-ethnic study of atherosclerosis.
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Sex differences in subclinical atherosclerosis by race/ethnicity in the multi-ethnic study of atherosclerosis.

机译:在多族裔动脉粥样硬化研究中,按种族/民族划分的亚临床动脉粥样硬化性别差异。

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摘要

Sex differences in cardiovascular disease mortality are more pronounced among non-Hispanic whites than other racial/ethnic groups, but it is unknown whether this variation is present in the earlier subclinical stages of disease. The authors examined racial/ethnic variation in sex differences in coronary artery calcification (CAC) and carotid intimal media thickness at baseline in 2000-2002 among participants (n = 6,726) in the Multi-Ethnic Study of Atherosclerosis using binomial and linear regression. Models adjusted for risk factors in several stages: age, traditional cardiovascular disease risk factors, behavioral risk factors, psychosocial factors, and adult socioeconomic position. Women had a lower prevalence of any CAC and smaller amounts of CAC when present than men in all racial/ethnic groups. Sex differences in the prevalence of CAC were more pronounced in non-Hispanic whites than in African Americans and Chinese Americans after adjustment for traditional cardiovascular disease risk factors, and further adjustment for behavioral factors, psychosocial factors, and socioeconomic position did not modify these results (for race/sex, P(interaction) = 0.047). Similar patterns were observed for amount of CAC among adults with CAC. Racial/ethnic variation in sex differences for carotid intimal media thickness was less pronounced. In conclusion, coronary artery calcification is differentially patterned by sex across racial/ethnic groups.
机译:在非西班牙裔白人中,心血管疾病死亡率的性别差异比其他种族/族裔人群更为明显,但尚不清楚这种差异是否存在于疾病的早期亚临床阶段。作者使用二项式和线性回归分析了2000年至2002年基线(多层)的动脉粥样硬化多种族研究参与者(n = 6,726)中,基线时颈动脉钙化(CAC)和颈动脉内膜中层厚度的性别/种族差异。在多个阶段对风险因素进行了调整的模型:年龄,传统心血管疾病风险因素,行为风险因素,社会心理因素和成人的社会经济地位。在所有种族/族裔群体中,女性的任何CAC患病率均低于男性,而存在的CAC量则少于男性。在调整了传统的心血管疾病危险因素后,非西班牙裔白人中CAC患病率的性别差异比非裔美国人和华裔美国人更为明显,并且对行为因素,心理社会因素和社会经济地位的进一步调整并未改变这些结果(对于种族/性别,P(互动)= 0.047)。在患有CAC的成年人中,观察到相似的CAC量模式。颈动脉内膜中层厚度的性别差异的种族/种族差异不太明显。总之,在种族/族裔群体中,性别对性别的影响不同。

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