Sodium hydrogen sulfate as a catalyst for the synthesis of N,4-diaryl-6-methyl-1-methyl(phenyl)-2-thioxo-l,2,3,4-tetra-hydropyrimidine-5-carboxamides via the Biginelli reaction

摘要

N,4-Diaryl-6-methyl-l-methyl(phenyl)-2-thioxo-l,2,3,4-tetrahydropyrimidine-5-carboxamides were synthesized in three-component reaction of JV-aryl-3-oxobutanamides, aromatic aldehyde, and JV-methylthiourea (N-phenylthiourea) in ethanol in the presence of nontoxic, cheap sodium hydrogen sulfate as a catalyst. Products were obtained in moderate to high yields.