To examine prospectively the relation between alcohol consumption and pancreatic cancer risk, the authors analyzed data from the Netherlands Cohort Study. Participants were 120,852 persons who completed a baseline questionnaire in 1986. After 13.3 years of follow-up, 350 cases of pancreatic cancer (67% microscopically confirmed) were available for analysis. Compared with abstention, the highest category of alcohol consumption (>30 g/day of ethanol) was positively associated with pancreatic cancer risk (for all cases, rate ratio = 1.57, 95% confidence interval: 1.03, 2.39; P_(trend) = 0-12; for microscopically confirmed cases, rate ratio = 1.54, 95% confidence interval: 0.94, 2.54; P_(trend) = 0.22). In a subgroup of stable alcohol users (no change during the 5 years before baseline), a similarly increased risk of pancreatic cancer was found. This increased risk was limited to the first 7 years of follow-up. No associations were observed between consumption of specific alcoholic beverages and risk of pancreatic cancer. The associations were not modified by folate intake or smoking. Overall, these findings suggest an increased pancreatic cancer risk for persons with a high ethanol intake (>30 g/day). However, this increased risk was observed only during the first 7 years of follow-up.
展开▼
机译：为了前瞻性地研究饮酒与胰腺癌风险之间的关系，作者分析了来自荷兰队列研究的数据。参与者为120,852人，他们于1986年完成了基线调查问卷。在进行了13.3年的随访之后，有350例胰腺癌（经镜检证实为67％）可供分析。与戒酒相比，酒精摄入量最高的类别（> 30 g /天的乙醇）与胰腺癌的风险呈正相关（在所有病例中，发生率之比= 1.57，95％置信区间：1.03,2.39; P_（趋势）= 0-12;经显微镜确认的病例，比率为1.54，95％置信区间为0.94、2.54; P_（趋势）= 0.22）。在一个稳定的饮酒者亚组中（基线之前的5年中没有变化），发现胰腺癌的风险也有类似的增加。这种增加的风险仅限于随访的前7年。在食用特定的酒精饮料与胰腺癌的风险之间没有关联。叶酸摄入或吸烟并没有改变这种关联。总体而言，这些发现表明，高乙醇摄入量（> 30 g /天）的人罹患胰腺癌的风险增加。但是，仅在随访的前7年才观察到这种风险增加。
展开▼
