ANTI-FATIGUE ACTIVITIES OF TOONA SINENSIS AQUEOUS LEAF EXTRACT IN MICE SUBJECTED TO EXHAUSTIVE SWIMMING

摘要

Toona sinensis is a perennial deciduous tree commonly found in China that has traditionally been used as a health food and herbal medicine for the treatment of various diseases. Here we explored the anti-fatigue effect of TSL-1 (a bioactive fraction of T sinensis) in a mouse model. After 1 week of acclimation, 8-week-old ICR mice were fed with either a standard diet or a standard diet containing TSL-1 for 15 days and then subjected to swimming until exhaustion. All mice were immediately sacrificed after exhaustive swimming, and major metabolic substrates were measured in serum and liver. The results showed that feeding TSL-1 to mice significantly increased their maximum swimming times to exhaustion compared with those of the control group (P < 0.05). Furthermore, dietary TSL-1 decreased the levels of blood lactic acid, serum urea nitrogen, and liver malondialdehyde, and increased the activity of superoxide dismutase in serum. Therefore, the present study demonstrated that TSL-1 enhanced the endurance capacity of mice and decreased biochemical markers of fatigue.