Efficacy of Jerusalem Artichoke in Healthy Japanese with Postprandial Plasma Glucose Level: A Randomized, Double-blind, Placebo-controlled Study

摘要

Objective: The objective of this study is to examine how the ingestion of Jerusalem artichoke containing inulin contributes to inhibiting the increase of postprandial plasma glucose level.Methods: A randomized, placebo-controlled, double-blind study was conducted to elucidate how the ingestion of a supplement made from the Jerusalem artichoke containing inulin lowers blood glucose level. In this study we measured the postprandial plasma glucose level after OGTT as the primary outcome. Furthermore, adverse events were collected by means of a written questionnaire during the study.Results: From all of 61applicants,13 were eliminated due to not-meeting inclusion criteria. The 48 subjects were randomly assigned to an intervention group and made a start with ingestion. 21were withdrawn due to fever or business, and the remaining 27 subjects completed the study. Thus, data obtained with 27 subjects (KK:14 ) was used for the analysis of efficacy. At Visit1(0-week) and Visit 3 (12-week), a significant difference was observed between two groups; the changes from FPG to 0.5 h-OGTT. At 0-week, KK did not present a significant difference in 2 h-OGTT, meanwhile Placebo yielded a significant increase. Also, at 12-week, KK decreased compared to FPG in 2 h-OGTT, while no decrease was observed in Placebo. No adverse effects were observed after the ingestion of the test product. Conclusion: We found out that the ingestion of the supplement made from Jerusalem artichoke containing inulin contributed to inhibiting the increase of postprandial plasma glucose level. In addition, no safety-related matter occurred during the test period.