Attenuating Effect of Isomaltodextrin Contained in Bread on Postprandial Plasma Glucose Levels in Healthy Humans:A Randomized, Placebo-controlled, Double-blind Crossover Study

摘要

Objective: The purpose of this study was to examine whether isomaltodextrin (IMD) attenuates elevated blood glucose levels following meal intake.Methods: Overnight-fasted subjects (n=30) consumed bread (containing IMD or not containing IMD) with breakfast, and blood glucose levels were determined over time from immediately before to120 minutes after meal intake. The study was conducted with or without intake of 2.93 g of IMD in a double-blind crossover study.Results: No differences were observed in blood glucose levels over time after the meal between IMD intake and non-IMD intake in all subjects. However, a stratified analysis of subjects with a tendency for increased postprandial blood glucose levels showed a significant higher attenuating effect of IMD intake on blood glucose elevation compared with non-IMD intake in terms of blood glucose levels over time and area under the curve. Conclusion: Results of this study suggest that IMD attenuates elevated blood glucose levels following meal intake.