Multiple endocrine neoplasia–like syndrome in 24 baboons (        <i >PapioPapio        spp.)

Confer Alexandra; Owston Michael A.; Kumar Shyamesh; Dick Edward J.

摘要

Abstract > Multiple endocrine neoplasia (MEN) has not been reported in baboons, but this condition is well described in humans. An internal database was searched for all cases of concurrent endocrine hyperplasia and neoplasia in baboons. Twenty‐four baboons ( Papio spp.) with concurrent endocrine hyperplasia and neoplasia were identified. Twenty‐one baboons had lesions in two endocrine organs, two baboons had lesions in three organs, and one baboon had lesions in four organs. Ten baboons aligned with the MEN1 classification; 14 baboons did not match any current human MEN classification. We report 24 cases of MEN‐like syndrome in baboons. MEN1‐like lesions accounted for nearly half (41%) of the affected animals. Genetic analysis of baboons with MEN‐like syndrome could further elucidate the mechanisms of MEN and support the use of baboons as animal models for human MEN. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“JMP12376-ABS-ABS-0001”XML：LANG =“EN”> <标题类型=“main”>抽象</ title> >多个内分泌肿瘤（男性）没有在狒狒中报道，但这种情况在人类中很好地描述。在狒狒中搜索了一系列同时内分泌增生和肿瘤的内部数据库。鉴定了二十四只狒狒（瓜粒子</ i> spp。）鉴定了同时的内分泌增生和瘤形成。二十一只狒狒在两个内分泌器官中有病变，两只狒狒有三个器官的病变，一个狒狒有四个器官的病变。十狒狒与men1分类一致; 14个狒狒与当前的人类分类不符。我们在狒狒中报告24例男性综合征。 Men1样病变占近一半（41％）的受影响动物。男性综合征的狒狒的遗传分析可以进一步阐明男性的机制，并支持狒狒作为人类动物模型的使用。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Confer Alexandra&option=202" target="_blank" rel="nofollow">Confer Alexandra;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Owston Michael A.&option=202" target="_blank" rel="nofollow">Owston Michael A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kumar Shyamesh&option=202" target="_blank" rel="nofollow">Kumar Shyamesh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dick Edward J.&option=202" target="_blank" rel="nofollow">Dick Edward J.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio Texas;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio Texas;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio Texas;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio Texas;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=adrenal gland neoplasms&option=203" rel="nofollow">adrenal gland neoplasms;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pancreatic neoplasms&option=203" rel="nofollow">pancreatic neoplasms;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pituitary neoplasms&option=203" rel="nofollow">pituitary neoplasms;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=primate&option=203" rel="nofollow">primate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=thyroid neoplasms&option=203" rel="nofollow">thyroid neoplasms;</a> </p> <div class="translation"> 机译：肾上腺肿瘤;胰腺肿瘤;垂体肿瘤;灵长类动物;甲状腺肿瘤; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993253.html">Multiple endocrine neoplasia–like syndrome in 24 baboons ( <i >PapioPapio spp.)</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Confer Alexandra&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Confer Alexandra,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Owston Michael A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Owston Michael A.,</a> <a 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2014</span><span>,第9期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-60577_thesis/020222678362.html">血清内分泌激素水平在多囊卵巢综合征不同中医证型患者中的变化特征</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵立铭&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵立铭</a> <span> <a href="/conference-cn-60577/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2015中西医结合北京论坛 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031872939.html">嗜铬细胞瘤和副神经节瘤中多个肿瘤抑制基因异常甲基化的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=付春莉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 付春莉</a> <span> . 2011</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" 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</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130422711149.html">MEN1, THE GENE ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 1, MENIN POLYPEPTIDES, AND USES THEREOF</a> <b>[P]</b> . <span> 外国专利：  CA2283476C </span> <span> . 2012-08-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：MEN1，与多种内分泌型1型menen多肽相关的基因，及其用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130432993492.html"><I>MEN1</I>, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof</a> <b>[P]</b> . <span> 外国专利：  US7358347B1 </span> <span> . 2008-04-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：<I> MEN1 </ 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Multiple endocrine neoplasia–like syndrome in 24 baboons ( PapioPapio spp.)

摘要