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Diet‐induced early‐stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance

机译：饮食诱导的狒狒早期动脉粥样硬化：脂蛋白，血液发生和动脉依从性

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Abstract <section numbered="no" xml:id="jmp12283-sec-0001"> <title type="main">Background >The purpose of this study was to determine whether dietary manipulation can reliably induce early‐stage atherosclerosis and clinically relevant changes in vascular function in an established, well‐characterized non‐human primate model. </section> <section numbered="no" xml:id="jmp12283-sec-0002"> <title type="main">Methods > We fed 112 baboons a high‐cholesterol, high‐fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease ( <fc>CVD</fc> ) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. </section> <section numbered="no" xml:id="jmp12283-sec-0003"> <title type="main">Results > We observed evidence of atherosclerosis in all but one baboon fed the two‐year challenge diet. <fc>CVD</fc> risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. </section> <section numbered="no" xml:id="jmp12283-sec-0004"> <title type="main">Conclusions >Feeding baboons a high‐cholesterol, high‐fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“JMP12283-ABS-ABS-0001”XML：LANG =“en”> <标题类型=“main”>抽象</ title> <sectouned =“no”xml：id = “JMP12283-SEC-0001”> <标题类型=“main”>背景</标题> >本研究的目的是确定膳食操作是否可以可靠地诱导早期动脉粥样硬化和血管功能的临床相关变化成熟的，特征的非人类灵长类动物模型。</ p> </ section> <secteneded =“no”xml：id =“jmp12283-sec-0002”> <标题类型=“main”>方法</标题> >我们喂食112狒狒高胆固醇，高脂肪挑战饮食两年。我们测定心血管疾病的循环生物标志物（<FC> CVD </ FC>）风险，0,7和104周攻击;在104周内毫无威胁评估动脉符合性;并测量尸检三个主要动脉的动脉粥样硬化病变。 </ p> </部分> <部分编号=“否”XML：ID =“JMP12283-SEC-0003”> <标题类型=“MAIN”>结果</标题> <P>我们观察到动脉粥样硬化的证据但是一只狒狒给了两年的挑战饮食。与膳食对照动物相比，动脉病变的风险生物标志物，动脉病变的患病率，尺寸和复杂性，以及随之而来的动脉僵硬。 </ p> </ section> <部分编号=“否”XML：ID =“JMP12283-SEC-0004”> <标题类型=“main”>结论</标题> >喂养狒狒高胆固醇，两年的高脂饮食可靠地诱导动脉粥样硬化，具有风险因子谱，动脉病变和在人类中也看到的血管功能的变化。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第1期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mahaney Michael C.&option=202" target="_blank" rel="nofollow">Mahaney Michael C.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Karere Genesio M.&option=202" target="_blank" rel="nofollow">Karere Genesio M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rainwater David L.&option=202" target="_blank" rel="nofollow">Rainwater David L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Voruganti Venkata S.&option=202" target="_blank" rel="nofollow">Voruganti Venkata S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dick Edward J.&option=202" target="_blank" rel="nofollow">Dick Edward J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Owston Michael A.&option=202" target="_blank" rel="nofollow">Owston Michael A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rice Karen S.&option=202" target="_blank" rel="nofollow">Rice Karen S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cox Laura A.&option=202" target="_blank" rel="nofollow">Cox Laura A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Comuzzie Anthony G.&option=202" target="_blank" rel="nofollow">Comuzzie Anthony G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=VandeBerg John L.&option=202" target="_blank" rel="nofollow">VandeBerg John L.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>South Texas Diabetes and Obesity InstituteThe University of Texas Rio Grande ValleyBrownsville TX USA;</p> <p>Department of GeneticsTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Department of GeneticsTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Department of Nutrition and UNC Nutrition Research InstituteUniversity of North CarolinaKannapolis NC USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Southwest National Primate Research CenterTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Department of GeneticsTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>Department of GeneticsTexas Biomedical Research InstituteSan Antonio TX USA;</p> <p>South Texas Diabetes and Obesity InstituteThe University of Texas Rio Grande ValleyBrownsville TX USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cardiovascular disease&option=203" rel="nofollow">cardiovascular disease;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=high‐fat diet&option=203" rel="nofollow">high‐fat diet;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=non‐human primate&option=203" rel="nofollow">non‐human primate;</a> </p> <div class="translation"> 机译：心血管疾病;高脂饮食;非人灵长类动物; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993053.html">Diet‐induced early‐stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mahaney Michael C.&option=202" 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Rainwater,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：饮食诱导的狒狒早期动脉粥样硬化：脂蛋白，血液发生和动脉依从性</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201285767667.html">氟伐他汀对高脂饮食兔动脉粥样硬化发生的早期干预作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘群锋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘群锋</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周少春&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,周少春</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马虹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,马虹</a> <span> <a href="/journal-cn-5968/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 岭南心血管病杂志 </a> </span> <span> . 2001</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_acta-medicinae-universitatis-scientiae-technologiae-huazhong_thesis/0201246038653.html">脂蛋白诱导平滑肌细胞表达载脂蛋白E及其在动脉粥样硬化斑块中的表达</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=瞿智玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 瞿智玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓仲端&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邓仲端</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=从容&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,从容</a> <span> <a href="/journal-cn-6547/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 华中科技大学学报（医学版） </a> </span> <span> . 2003</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201285770775.html">高密度脂蛋白胆固醇和高密度脂蛋白颗粒与颈动脉粥样硬化发生及严重程度的相关性</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘蕾&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘蕾</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姜涛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,姜涛</a> <span> <a href="/journal-cn-5968/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 岭南心血管病杂志 </a> </span> <span> . 2017</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-practical-medical-techniques_thesis/0201290343453.html">D-二聚体低密度脂蛋白胆固醇和血清脂蛋白a联合检测在早期冠状动脉粥样硬化性心脏病中的诊断价值</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李意贤&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李意贤</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黎华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黎华</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=潘志明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,潘志明</a> <span> <a href="/journal-cn-6654/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 实用医技杂志 </a> </span> <span> . 2021</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_advances-cardiovascular-diseases_thesis/0201231259248.html">通过富含甘油三酯的脂蛋白中载脂蛋白CI含量独立预测健康中年人早期的动脉粥样硬化</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张宇辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张宇辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张代富&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张代富</a> <span> <a href="/journal-cn-5989/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 心血管病学进展 </a> </span> <span> . 2006</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-61698_thesis/020222738320.html">高磷血症通过诱导胆固醇敏感器SCAP功能失调促进ApoE-/-小鼠动脉粥样硬化的发生与发展</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘巧&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘巧</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=欧阳南&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,欧阳南</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=何泉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,何泉</a> <span> <a href="/conference-cn-61698/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第19届中国南方国际心血管病学术会议 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313452222.html">miR-17-5p通过调控极低密度脂蛋白受体的表达参与动脉粥样硬化发生机制的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谭力力&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 谭力力</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120100911441.html">用于降低脂蛋白颗粒对动脉壁酶引起的致动脉粥样硬化性聚集的敏感度的方法和试剂盒</a> <b>[P]</b> . <span> 中国专利： CN109789217A </span> <span> . 2019-05-21</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120109542606.html">抵抗饮食诱导肥胖的猪R型载脂蛋白基因及猪R型载脂蛋白</a> <b>[P]</b> . <span> 中国专利： CN107058331A </span> <span> . 2017-08-18</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130446738139.html">Antibodies for malondialdehyde low density lipoproteins and oxidised low density lipoproteins for detection of arterial diseases such as atherosclerosis</a> <b>[P]</b> . <span> 外国专利： <!-- --> NZ502369A </span> <span> . 2001-11-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：丙二醛低密度脂蛋白和氧化型低密度脂蛋白的抗体，用于检测动脉疾病，例如动脉粥样硬化 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130420375584.html">use of low density oxidized lipoprotein immunotherapy, method for inducing regression of atherosclerotic plaques in an individual, use of at least one ldl antibody or at least one oxidized epitope of ldl, method for combating cardiovascular disease associated with atherosclerosis, use of at least an antibody molecule or at least one oxidized epitope of ldl and a statin, pharmaceutical formulation, part kit, methods for identifying an antibody that induces regression of atherosclerotic plaques in an individual and for identifying an agent that induces regression of atherosclerotic plaques in an individual, antibody, pharmaceutical composition, and antibody use</a> <b>[P]</b> . <span> 外国专利： <!-- --> BRPI0615313A2 </span> <span> . 2012-12-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：低密度氧化脂蛋白免疫疗法的应用，在个体中诱导动脉粥样硬化斑块消退的方法，至少一种ldl抗体或ldl的至少一种氧化表位的使用，与动脉粥样硬化相关的心血管疾病的防治方法，至少一种抗体的使用分子和至少一种Idl的氧化表位和他汀类药物，药物制剂，部分试剂盒，鉴定在个体中诱导动脉粥样硬化斑块消退的抗体和鉴定在个体中诱导动脉粥样硬化斑块消退的药剂的方法，抗体，药物组合物和抗体用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130452671965.html">Compound pharmaceutical compound and processes to antagonize endothelin to treat hypertension congestive heart failure restenosis following arterial lesion cerebral or myocardial ischemia or atherosclerosis coronary angina cerebral vasospasm acute renal failure and chronic gastric ulceration cyclosporine-induced nephrotic toxicity endotoxin-induced endotoxin-induced toxicity by endotoxin with lpl proliferative diseases acute pulmonary hypertension or chronic platelet aggregation tombose cardiotoxicity mediated by il-2 nonciception colitis disorder of vascular permeabulity lesion by reperfusion-ischemia deraynaud disease and migraine and to prepare a compound.</a> <b>[P]</b> . <span> 外国专利： <!-- --> BR9707509A </span> <span> . 1999-07-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：拮抗内皮素的复合药物化合物和方法，可治疗动脉病变脑或心肌缺血或动脉粥样硬化后的高血压充血性心力衰竭再狭窄冠心绞痛脑血管痉挛急性肾衰竭和慢性胃溃疡环孢素诱导的肾病毒性内毒素诱导的内毒素诱导的毒性lpl增生性疾病急性肺动脉高压或慢性血小板聚集性tombose心脏毒性是由il-2介导的非渗透性皮炎病灶和再灌注缺血性偏头痛所致的il-2非感受性结肠炎疾病所介导的。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 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