Analysis of Prognostic Risk Factors in Patients with Nasopharyngeal Carcinoma Treated with Radiotherapy by Magnetic Resonance Imaging

摘要

The purpose of the study was to explore the application value of magnetic resonance imaging (MRI) technology in the study of the prognosis of patients with nasopharyngeal carcinoma (NPC) after radiotherapy, and to analyze the risk factors leading to imaging residues, so as to provide reference for the treatment and prognosis of patients with NPC. The clinical data of 691 patients with NPC hospitalized from June 2008 to June 2016 were retrospectively analyzed. According to the results of magnetic resonance medical imaging, the residual data of patients with NPC after treatment were analyzed. Combined with t-stage and n-stage parameters, the image residual was divided into t-stage residual and n-stage residual. The radiological residues, residual regression time, survival time, recurrence and metastasis time were recorded. The radiological residual rate of NPC after radiotherapy was calculated, and the differences among groups were compared by chi-square test. The risk factors of image residual and residual regression time were analyzed by logistic regression model. The 5-year overall survival rate (OS), 5-year recurrence-free survival rate (LRFS), and 5-year distant metastasis-free survival rate (DMF) were calculated. Kaplan-Meier method was used to analyze the influence of various factors on the prognosis of patients, and logarithmic rank test was used to compare the difference of survival rate between the two groups. The results showed that the residual rate of T and N was 32.9% and 31.0% at the end of radiotherapy for NPC. In summary, magnetic resonance medical imaging technology can effectively evaluate the prognostic risk factors of patients with NPC after radiotherapy. Male, elderly, radioactivity residue, and high stage are the risk factors affecting the prognosis of patients with NPC after radiotherapy. The recurrence and metastasis of NPC patients can be effectively controlled by means of emphasizing radiotherapy combined with adjuvant chemotherapy.