首页> 外文期刊>Journal of viral hepatitis. >Neuropsychiatric symptoms in hepatitis C patients resemble those of patients with autoimmune liver disease but are different from those in hepatitis B patients
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Neuropsychiatric symptoms in hepatitis C patients resemble those of patients with autoimmune liver disease but are different from those in hepatitis B patients

机译:丙型肝炎患者的神经精神症状类似于自身免疫性肝病患者的患者,但与乙型肝炎患者的患者不同

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Summary Chronic fatigue, mood alterations and cognitive impairment are frequent accessory symptoms of HCV infection. Fatigue and mood alterations have also been observed in autoimmune hepatitis ( AIH ) and primary biliary cholangitis ( PBC ), but not in hepatitis B virus ( HBV )‐infection, thus indicating an autoimmune response as possible cause of HCV infection‐associated encephalopathy. Data, however, are sparse. This study aimed to prove that HCV patients feature similar to those with autoimmune liver disease but contrary to HBV patients regarding neuropsychiatric symptoms. A total of 132 noncirrhotic patients ( HCV : 46, HBV : 22, AIH : 27, PBC : 29, AIH / PBC : 8) completed questionnaires addressing the domains mentioned above. Eighty‐eight underwent a comprehensive neuropsychological assessment. Patient groups were compared among each other and to 33 healthy controls. Fatigue, anxiety and depression scores were significantly increased, and the SF ‐36 mental score significantly decreased in all patient groups compared to controls. Fatigue was significantly more pronounced in HCV than in HBV patients. HCV patients scored significantly worse than HBV patients but not AIH and PBC patients in the SF ‐36. HCV , AIH and PBC but not HBV patients did significantly worse than controls in word learning. Recognition of words was impaired in HCV , AIH and PBC patients and recognition of figures in HCV patients, exclusively ( P ?≤?0.002). HCV patients did also worse than controls and HBV patients concerning alertness and working memory ( P ?≤?0.001). The neuropsychiatric profiles of HCV patients are similar to those of AIH and PBC patients but differ from those of HBV patients, suggesting an autoimmune response as a possible cause for these differences.
机译:发明内容慢性疲劳,情绪改变和认知障碍是HCV感染的常见辅助症状。在自身免疫性肝炎(AIH)和原发性胆管炎(PBC)中也观察到疲劳和情绪改变,但不在乙型肝炎病毒(HBV)中,从而表明作为HCV感染相关脑病的可能原因的自身免疫反应。但是,数据稀疏。本研究旨在证明HCV患者的特征与具有自身免疫性肝病的HCV患者特征,但与有关神经精神症状的HBV患者相反。共有132名非抑弹患者(HCV:46,HBV:22,AIH:27,PBC:29,AIH / PBC:8)完成了解决上述域名的问卷。八十八篇经过全面的神经心理学评估。患有患者群体相互比较和33例健康对照。疲劳,焦虑和抑郁分数明显增加,与对照组相比,所有患者组的SF -36精神分数明显降低。 HCV在HBV患者中疲劳显着显着显着。 HCV患者比HBV患者均显着较差,但在SF -36中没有AIH和PBC患者。 HCV,AIH和PBC,但没有HBV患者比在学习中的控制中显着差。 HCV,AIH和PBC患者的识别患者受到损害,并识别HCV患者中的图,专门(P?≤≤002)。 HCV患者也比有关警觉性和工作记忆的控制和HBV患者更差(P?≤≤0.001)。 HCV患者的神经精神谱与AIH和PBC患者的患者类似,但与HBV患者的患者有所不同,表明自身免疫反应作为这些差异的可能原因。

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