Effect of polymerizable quaternary ammonium monomer MEIM-x's alkyl chain length and content on bone cement's antibacterial activity and physicochemical properties

摘要

Quaternary ammonium monomers with N-alkyl chain length varied from 6 to 18, namely MEIM-x(x?=?6–18), were incorporated into acrylic bone cements to prepare antibacterial bone cements. With the increasing of MEIM-x's alkyl chain length, the MEIM-x monomers’ minimum inhibitory concentrations (MIC) decreased to 8?μg/mL and 2?μg/mL (MEIM-14, forE. coliandS. aureus,respectively) at first and then increased. The 50% hemolytic concentrations (HC50) decreased monotonously with the increasing of alkyl chain length. The bone cements contained 2% and 5% of long-chain MEIM-x (x?≥?10) showed significant antibacterial activity againstE. coliandS. aureus, while the bone cements contained short-chain MEIM-x(x?