Effect of Helianthus tuberosus Juice Mixed with Dried Bitter Melon Juice on Hypoglycemic Function in Streptozotocin-Induced Diabetic Rats

摘要

This study was conducted to develop Helianthus tuberosus (HT) juice mixed with dried bitter melon juice and assess its hypoglycemic effect in streptozotocin (STZ)-induced diabetic rats. HT juice mixed with 5.0% dried bitter melon juice was used in this study. Male Sprague-Dawley rats were divided into four groups (eight rats per group) and drunk each sample for 4 weeks: normal water [normal control (NC) group], STZ+normal water (STZ group), STZ+HT juice (HT group), STZ+HT juice mixed with 2.5% bittermelon juice (HT2.5 group), and STZ+HT juice mixed with 5.0% bitter melon juice (HT5.0 group). HT juice was diluted to 25% in distilled water and supplied to rats. Food intake, body weight gain, and food efficiency ratio were lower in the STZ group thanin the NC group. HT, HT2.5, and HT5.0 groups showed higher parameters than the STZ groups. Water intakes were higher in the STZ group than in the NC group. After 3 weeks, HT, HT2.5, and HT5.0 groups showed lower parameters than the STZ group. After 1 week, blood glucose level of the STZ group (476.7±22.8 mg/dL) was significantly higher than those of the HT group (376.3±25.8 mg/dL), HT2.5 group (405.2±35.1 mg/dL), and HT5.0 group (342.8±29.7 mg/dL). After 4 weeks, blood glucose level of the STZ groupwere significantly higher than those of the HT, HT2.5, and HT5.0 group. Serum insulin levels of the HT group (3.13±0.32 ng/mL), HT2.5 group (3.40±0.23 ng/mL), and HT5.0 group (3.48±0.43 ng/mL) were higher than that of the STZ group (2.72±0.53 ng/mL). These results indicate that H. tuberosus juice mixed with dried bitter melon juice helps prevent or attenuate progression of diabetes in rats with STZ-induced diabetes.