BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma

Blair Alex B.; Groot Vincent P.; Gemenetzis Georgios; Wei Jishu; Cameron John L.; Weiss Matthew J.; Goggins Michael; Wolfgang Christopher L.; Yu Jun; He Jin

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BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma

机译：BRCA1 / BRCA2种系突变载体和散发性胰腺导管腺癌

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BACKGROUND: The outcomes of sporadic pancreatic ductal adenocarcinoma (PDAC) patients with germline mutations of BRCA1/BRCA2 remains unclear. The prognostic significance of BRCA1/BRCA2 mutations on survival is not well established.

机译：背景：BRCA1 / BRCA2的种系突变患者的散孔胰腺导管腺癌（PDAC）患者的结果仍不清楚。 BRCA1 / BRCA2突变对存活率的预后意义并不明确。

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《Journal of the American College of Surgeons》 |2018年第4期|共8页
作者
Blair Alex B.; Groot Vincent P.; Gemenetzis Georgios; Wei Jishu; Cameron John L.; Weiss Matthew J.; Goggins Michael; Wolfgang Christopher L.; Yu Jun; He Jin;
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作者单位

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Oncol Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

Johns Hopkins Med Inst Dept Surg Sol Goldman Pancreat Canc Res Ctr Baltimore MD 21205 USA;

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正文语种 eng
中图分类外科学;
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1. BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma [J] . Blair Alex B., Groot Vincent P., Gemenetzis Georgios, Journal of the American College of Surgeons . 2018,第4期

机译：BRCA1 / BRCA2种系突变载体和散发性胰腺导管腺癌
2. BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma Discussion [J] . Fleming Jason, Vickers Selwyn, Merchant Nipun, Journal of the American College of Surgeons . 2018,第4期

机译：BRCA1 / BRCA2种系突变载体和散发性胰腺导管腺癌讨论
3. Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma [J] . Obazee O., Archibugi L., Andriulli A., International Journal of Cancer =: Journal International du Cancer . 2019,第3期

机译：Germline BRCA2 K3326X和Chek2 I157T突变增加了散发性胰腺导管腺癌的风险
4. A Fast and Reliable Amplicon-Based NGS Strategy for Screening of Germ-Line Mutations in BRCA1 and BRCA2 Genes [C] . Dawn Obermoeller, Jiri Nehyba, Radmila Hrdlickova, International Molecular Medicine Tri-Conference. . 2016

机译：基于快速且可靠的扩增子NGS策略，用于筛选BRCA1和BRCA2基因的细菌突变
5. BRCA1 and BRCA2 Mutation Carrier Perspectives on Direct-to-Consumer Genetic Testing for BRCA Mutations [D] . Mitchell, Caitlyn E. 2019

机译：BRCA1和BRCA2突变载体对BRCA突变的直接消费遗传检测的视角
6. BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma [O] . Alex B Blair, Vincent P Groot, Georgios Gemenetzis, -1

机译：BRCA1 / BRCA2生殖细胞突变载体和散发性胰腺导管腺癌。
7. BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma [O] . Alex B. Blair, Vincent P. Groot, Georgios Gemenetzis, 2018

机译：BRCA1 / BRCA2种系突变载体和散发性胰腺导管腺癌

BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma

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