A New Gas Chromatography–Mass Spectrometry Method for Detecting and Quantifying Low Levels of Dimethyl Sulfate in Palm Oil‐Based Sulfonated Methyl Esters

Ping Bonnie Tay Yen; Aziz Haliza Abdul

摘要

Abstract > Dimethyl sulfate (DMS) is a potential carcinogen that may be formed during the production of α‐sulfonated methyl ester (α‐SME). To date, there have been no published analytical methods for quantification of DMS in palm oil‐based α‐SME. The objective of the method development was to establish a simple and reliable method for quantifying and monitoring DMS from palm oil‐based α‐SME. The sample preparation prior to analysis involved extracting DMS from α‐SME using hexane. The gas chromatography–mass spectrometry (GC–MS) separation was performed on an Agilent MS‐HP5 column (30?m × 320?μm × 0.25?μm). The MS signal was obtained in the selected ion monitoring (SIM) mode. The method was validated according to the International Conference on Harmonization (ICH) guidelines. The accuracy of the method was measured via percentage recoveries of DMS from spiked α‐SME samples at spiking levels of (25, 125, 250, and 500) μg mL ?1 . The percentage recoveries for all spiking levels were found to be in the range of 88.6–97.4%. The repeatability and interday reproducibility were found to be satisfactory as the relative standard deviations (RSD) were within 11%. The method also has a good linear relationship as indicated by the coefficient of determination of 0.9996 over the range of 1.0–30?μg?mL ?1 . The limits of detection (LOD) and quantification (LOQ) corresponded to 0.8 and 2.3?μg?mL ?1 , respectively. The developed method demonstrated sufficient linearity, intraday and interday precision, sensitivity, and accuracy for determination of DMS in palm oil‐based α‐SME. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 二甲基硫酸酯（DMS）是可以在制备α-磺化甲酯（α-SME）期间形成的潜在致癌物。迄今为止，没有公布的棕榈油基α-SME中DMS的分析方法。该方法开发的目的是建立一种简单可靠的方法，用于从掌上基于棕榈油的α-SME量化和监测DMS。在分析之前的样品制剂涉及使用己烷从α-SME提取DMS。在Agilent MS-HP5柱上进行气相色谱 - 质谱（GC-MS）分离（30≤m×320μm×0.25≤μm）。在所选的离子监测（SIM）模式中获得MS信号。该方法根据协调会议（ICH）指导方针进行验证。测量方法的准确性通过</ i> Spikedα-SME样品中DMS的百分比百分比（25,125,250和500）μgml ？1 </ sup> 。发现所有尖峰水平的百分比率为88.6-97.4％。由于相对标准偏差（RSD）在11％以内，重复性和白天的重复性被认为是令人满意的。该方法还具有良好的线性关系，如0.9996的测定系数所示在1.0-30≤μg的范围内？1 </ sup> 。检测限（LOD）和定量（LOQ）对应于0.8和2.3ΩΩml ？1 </ sup> ，分别。开发方法展示了足够的线性，日内和白天精度，灵敏度和准确性，用于测定棕榈油基α-SME中的DMS。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35863/'>《Journal of Surfactants and Detergents》</a> <b style="margin: 0 2px;">|</b><span>2019年第4期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ping Bonnie Tay Yen&option=202" target="_blank" rel="nofollow">Ping Bonnie Tay Yen;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Aziz Haliza Abdul&option=202" target="_blank" rel="nofollow">Aziz Haliza Abdul;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Advanced Oleochemical Technology DivisionPersiaran Institusi Bandar Baru BangiSelangor Malaysia;</p> <p>Advanced Oleochemical Technology DivisionPersiaran Institusi Bandar Baru BangiSelangor Malaysia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4818.html" title="表面现象的物理化学">表面现象的物理化学;</a><a href="https://www.zhangqiaokeyan.com/clc/7878.html" title="表面活性剂">表面活性剂;</a><a href="https://www.zhangqiaokeyan.com/clc/1844.html" title="油脂和蜡的化学加工工业、肥皂工业">油脂和蜡的化学加工工业、肥皂工业;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=α‐Sulfonated methyl ester&option=203" rel="nofollow">α‐Sulfonated methyl ester;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Palm oil&option=203" rel="nofollow">Palm oil;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=By‐products&option=203" rel="nofollow">By‐products;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Detergent&option=203" rel="nofollow">Detergent;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Surfactant&option=203" rel="nofollow">Surfactant;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Genotoxic&option=203" rel="nofollow">Genotoxic;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dimethyl sulfate&option=203" rel="nofollow">Dimethyl sulfate;</a> </p> <div class="translation"> 机译：α-磺化甲酯;棕榈油;副产品;洗涤剂;表面活性剂;基因毒性;硫酸二甲基; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025864250.html">A New Gas Chromatography–Mass Spectrometry Method for Detecting and Quantifying Low Levels of Dimethyl Sulfate in Palm Oil‐Based Sulfonated Methyl Esters</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ping Bonnie Tay Yen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ping Bonnie Tay Yen,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Aziz Haliza Abdul&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Aziz Haliza Abdul </a> <a href="/journal-foreign-35863/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Surfactants and Detergents .</a> <span>2019</span><span>,第4期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一种新的气相色谱 - 质谱法，用于检测和定量棕榈油基磺化甲酯中低水平的硫酸二甲基硫酸酯</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020639916.html">A gas chromatography full scan high resolution Orbitrap mass spectrometry method for separation and characterization of 3-hydroxymethyl pyridine ester of fatty acids at low levels</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Merlier Franck&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Merlier Franck,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Imatoukene Nabila&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Imatoukene Nabila,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Octave Stephane&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Octave Stephane,</a> <a href="/journal-foreign-34102/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of chromatography, A: Including electrophoresis and other separation methods .</a> <span>2018</span><span>,第期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一种气相色谱全扫描高分辨率眶谱法，用于低水平脂肪酸3-羟甲基吡啶酯的分离和表征</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025474796.html">A sensitive method for the separation and quantification of low-level adenine nucleotides using porous graphitic carbon-based liquid chromatography and tandem mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sonia Bustamante&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sonia Bustamante,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Robert B. 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href="/academic-journal-cn_guangdong-chemical-industry_thesis/0201281382262.html">气相色谱-质谱法测定土壤中硫酸二甲酯和硫酸二乙酯的残留量</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯萌萌&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 冯萌萌</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王虹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王虹</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈佩瑾&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈佩瑾</a> <span> <a href="/journal-cn-9122/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 广东化工 </a> </span> <span> . 2020</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_fujian-analysis-testing_thesis/0201211774968.html">超声萃取-气相色谱-串联质谱法测定纺织品中硫酸二甲酯和硫酸二乙酯的残留量</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=林君峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 林君峰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=麦志喜&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,麦志喜</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王成云&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王成云</a> <span> <a href="/journal-cn-7656/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 福建分析测试 </a> </span> <span> . 2017</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-39312_thesis/020222422603.html">气相色谱-质谱法测定药品中残留的硫酸二甲酯和硫酸二乙酯</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=史迎杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 史迎杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=温静&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,温静</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵新颖&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵新颖</a> <span> <a href="/conference-cn-39312/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第四届环渤海色谱质谱学术报告会 </a> <span> <span> . 2016</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031132195.html">一种新的PRL-3的抑制剂(桑色素-7-硫酸酯钠)抗黑色素瘤细胞转移的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王雯娟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王雯娟</a> <span> . 2013</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" 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<span>机译：直接从蜂蜜中鉴定和定量草甘膦产物和代谢产物甲基-甲基膦酸的方法，方法是采用液相色谱-质谱联用后的分析萃取。 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130422148767.html">METHOD AND AN APPARATUS FOR CLASSIFYING ARTEMISIA SPECIES AND THE DRIED LEAF OF THE ARTEMISIA ASIATICA CAPABLE OF ACCURATELY ANALYZING THE METABOLOME OF ARTEMISIA BASED ON A GAS CHROMATOGRAPHY/MASS SPECTROMETRY OR LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY METABOLOMICS ANALYSIS</a> <b>[P]</b> . <span> 外国专利：  KR20110125373A </span> <span> . 2011-11-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于气相色谱/质谱或液相色谱/质谱分析法对蒿属菌种和干蒿进行分类的方法和装置，能够准确地分析蒿属的代谢 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130412289976.html">Gas chromatography-mass spectrometry method and gas chromatography-mass spectrometry apparatus therefor having a capture and release device</a> <b>[P]</b> . <span> 外国专利：  US9228984B2 </span> <span> . 2016-01-05</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：具有捕获和释放装置的气相色谱-质谱法及其气相色谱-质谱仪 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025864250','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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