Copper-based metal coordination complexes with Voriconazole ligand: Syntheses, structures and antimicrobial properties

摘要

AbstractThree new chiral metal coordination complexes, namely, [Cu(FZ)2(CH3COO)2(H2O)]·2H2O (1), [Cu(FZ)2(NO3)2] (2), and [Cu2(FZ)2(H2O)8](SO4)2·4H2O (3) [FZ= (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidiny)-1-(1H-1,2,4-triazol-1-yl)-2-butanol) (Voriconazole)] have been obtained by the reaction of Cu(II) salts and the free ligandFZat room temperature. Complexes1–3were structurally characterized by X-ray single-crystal diffraction, IR, UV–vis, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). Complex1crystallizes in the chiral space groupC2, which exhibits a mono-nuclear structure. Both complexes2and3display a one-dimensional (1D) tape structure, which crystallize in chiral space groupP21212 andP212121