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首页> 外文期刊>American Journal of Biochemistry and Biotechnology >Soluble CD14, Sialic Acid and L-Fucose in Breast Milk and their Role in Increasing the Immunity of Breast-Fed Infants
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Soluble CD14, Sialic Acid and L-Fucose in Breast Milk and their Role in Increasing the Immunity of Breast-Fed Infants

机译:母乳中的可溶性CD14,唾液酸和L-岩藻糖及其在提高母乳喂养婴儿免疫力中的作用

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Problem statement: Breast milk contain protective factors as soluble CD 14, L-Fucose and Sialic acid which increase the innate immunity and level of intelligence, decrease the incidence of gastroenteritis, chest and other systemic diseases in newly born infants. In the present study the role of soluble CD 14, L-Fucose and Sialic acid, in increasing the immunity in breastfed infants were studied to establish the previously unrecognized function and their broader spectrum of activities. Approach: The study was carried out with three different groups of breastfed neonates/infants; In group-I twenty full term neonate aging from (1-29 days), group-II fifteen pre-term neonates aging from (1-29 days) and in group-Ill fifteen infants aging from (61-730 days) were selected and their health were studied. Results: The results showed that the levels of sCD14 were 16.47 ± 5.50, 17.07 ± 5.86 and>5 .10± 3.45 mu g mL~(-1) in full term, pre-term and 2-years group respectively. The levels of sialic acid were 2.5-3 folds higher in group-I (3.29±L34 mmol L~(-1)) and group-II (3.99 ± 1.32 mmol L~(-1)), as compared to group-Ill (1.30 ±0.16 mmol L~(-1)) repectively. Similarly, the level of L-Fucose was 1.5 folds higher in group-I (8.84 ± 0.34 mmol L~(-1)) and group-II (8.92 ± 0.37 mmol L~(-1)) as compared to group-Ill (5.80 ± 1.96 mmol L~(-1)). Conclusion: Breast milk contains a variety of antimicrobial substances (relatively resistant against intestinal proteolysis) that functions in safeguarding the lactating mammary gland and provides protection to the suckling infant at a time when its immune system is still immature, some of these substances include sCD14, Sialic acid and L-Fucose. Hence, it is recommended to breastfeed the neonates/infants to enhance their immunity.
机译:问题陈述:母乳含有可溶性CD 14,L-岩藻糖和唾液酸等保护因子,可增加先天免疫力和智力水平,降低新生婴儿胃肠炎,胸腔及其他全身性疾病的发生率。在本研究中,对可溶性CD 14,L-岩藻糖和唾液酸在提高母乳喂养婴儿免疫力中的作用进行了研究,以建立以前无法识别的功能和更广泛的活性范围。方法:该研究是针对三组不同的母乳喂养的新生儿/婴儿进行的。在第I组中,从(1-29天)开始的20个足月新生儿,在II组中,从(1-29天)的15个早产新生儿中选择,在第II组中,从(61-730天)的15个婴儿中选出。和他们的健康进行了研究。结果:足月,早产和2年组sCD14水平分别为16.47±5.50、17.07±5.86和> 5.10±3.45μgmL〜(-1)。与III组相比,I组(3.29±L34 mmol L〜(-1))和II组(3.99±1.32 mmol L〜(-1))的唾液酸水平高2.5-3倍。分别为(1.30±0.16 mmol L〜(-1))。类似地,与III组相比,I组(8.84±0.34 mmol L〜(-1))和II组(8.92±0.37 mmol L〜(-1))的L-岩藻糖水平高1.5倍。 (5.80±1.96 mmol L〜(-1))。结论:母乳含有多种抗微生物物质(对肠蛋白水解相对抗性),可起到保护哺乳期乳腺的作用,并在其免疫系统仍不成熟时为哺乳婴儿提供保护,其中一些物质包括sCD14,唾液酸和L-岩藻糖。因此,建议母乳喂养新生儿/婴儿以增强其免疫力。

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