首页> 外文期刊>Journal of Photochemistry and Photobiology, B. Biology: Official Journal of the European Society for Photobiology >Rapid biosynthesis and characterization of silver nanoparticles from the leaf it extract of Tropaeolum majus L. and its enhanced in-vitro antibacterial, antifungal, antioxidant and anticancer properties
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Rapid biosynthesis and characterization of silver nanoparticles from the leaf it extract of Tropaeolum majus L. and its enhanced in-vitro antibacterial, antifungal, antioxidant and anticancer properties

机译:Hotingoolum Majus L中的叶片中银纳米粒子的快速生物合成及其表征及其增强的体外抗菌,抗氧化,抗氧化和抗癌性能

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Eco-friendly biosynthesis of nanoparticles from medicinal plants as reducing agent has gained importance due to its potential therapeutic uses. In the present study Silver nanoparticles (AgNPs) were eco-friendly synthesized using the leaf extracts of the medicinal plant Tropaeolum majus. The obtained AgNPs were characterized by UV - visible spectrum, FTIR, SEM and XRD which clearly showed the reduction of Ag+ ions to Ag-0. In addition, the aqueous and ethanolic extracts were analyzed for phytochemicals and its antioxidant activities. GC-MS spectrum showed the presence of 25 compounds with benzeneacetic acid as the dominant contents. The synthesized AgNPs revealed maximum absorption spectrum at 463 nm and FTIR vibrational peaks at 3357.46, 21,966.52, 2118.42, 1637.27, 658.571 and 411.728 cm(-1) respectively. SEM and XRD studies evidenced the nature of nanocrystalline with face centered cubic (fcc) crystal structure. Both AgNPs and plant extracts showed more inhibition activity against Pseudomonas aeroginosa compared to other bacteria with MIC value of 6.25 mu g/ml. Antifungal activities was higher for Penicilium notattun with MIC value 31.2 mu g/ml. The IC50 values for MCF7 for aqueous extract were found to be 4.68 mu g/ml, ethanol extract 7.5 mu g/ml, AgNPs 2.49 mu g/ml, and doxorubicin 1.4 mu g/ml. The IC50 values for VERO cell line for aqueous extract was 8.1 mu g/ml, ethanol extract with 6.8 mu g/ml, silver nanoparticles 5.3 mu g/ml and doxorubicin 2.6 mu g/ml respectively. Conclusively, the antibacterial, anti fungal, antioxidant and anticancer properties of the synthesized AgNPs from Tropaeolum majus act as major therapeutic drug for microbial infectious disease and other health associated disorders.
机译:由于其潜在的治疗用途,来自药用植物的纳米颗粒的环状化合物生物合成产生了重要性。在本研究中,使用药用植物Tropaeolum Majus的叶子提取物进行银纳米颗粒(AgNP)。通过UV - 可见光谱,FTIR,SEM和XRD的特征在于,所述AgNPS清楚地表现出Ag-0的减少。此外,分析水性和乙醇萃取物用于植物化学物质及其抗氧化剂活性。 GC-MS光谱显示出25种具有苯甲酸的化合物作为主要内容物。合成的AgNP分别在3357.46,21,966.52,2118.42,1637.27,658.571和411.728cm(-1)下显示出在463nm和ftir振动峰处的最大吸收光谱。 SEM和XRD研究证明了纳米晶体的性质与面为中心立方(FCC)晶体结构。与具有6.25μg/ mL的MIC值的其他细菌相比,AgNP和植物提取物均显示对Pseudomonas aeroginosa的抑制活性。对于Penicilium Notatrun,MIC值31.2μg/ ml,抗真菌活性更高。将用于含水提取物的MCF7的IC 50值为4.68μg/ ml,乙醇提取物7.5μg/ ml,agnps2.49μg/ ml,和多柔比星1.4μg/ ml。用于含水提取物的VERO细胞系的IC 50值为8.1μg/ ml,乙醇萃取物,含有6.8μg/ ml,银纳米颗粒5.3μg/ ml和多柔比星2.6μg/ mL。结论,来自对Tropaeolum Majus的合成AgNP的抗菌,抗真菌,抗氧化剂和抗氧化剂和抗癌性能作为微生物传染病和其他健康相关障碍的主要治疗药物。

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