Trends in emergency hospital admissions in England due to adverse drug reactions: 2008–2015

机译：由于不良药物反应，英格兰急诊医院入学趋势：2008-2015

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Abstract <section xml:id="jphs12160-sec-0001"> <title type="main">Objectives > To determine the scale of adverse drug reaction ( <fc>ADR</fc> )‐related emergency hospital admissions in England from 2008 to 2015 using the Hospital Episode Statistics ( <fc>HES</fc> ) database. </section> <section xml:id="jphs12160-sec-0002"> <title type="main">Methods > Part of the <fc>HES</fc> database contains information about all hospital admissions in England. Annual data are published online and are publically available. These hospital admission data were analysed to determine how many emergency admissions were due to <fc>ADR</fc> s. International classification of diseases, 10th edition ( <fc>ICD</fc> ‐10) codes that indicated a drug was the primary cause of the admission were included in the study. </section> <section xml:id="jphs12160-sec-0003"> <title type="main">Key findings > The total number of emergency hospital admissions increased by 12.1%, from 5 010 670 in 2008/2009 to 5 615 707 in 2014/2015. Over the same period, emergency admissions due to <fc>ADR</fc> s increased by 53.4%, from 60 055 in 2008/2009 to 92 114 in 2014/2015. These figures indicate an increase in the proportion of emergency hospital admissions due to <fc>ADR</fc> s over the period of study, from 1.2% in 2008/2009 to 1.6% in 2014/2015. > The total number of bed days utilised decreased by 7.1%, from 51 841 443 in 2008/2009 to 48 183 084 in 2014/2015. Despite this overall decrease, the number of bed days that were used due to <fc>ADR</fc> s increased by 51.5% from 625 011 (1.2% of all bed days) in 2008/2009 to 947 016 (2.0% of all bed days) in 2014/2015. > The most common <fc>ADR</fc> s were mental and behavioural disorders due to drugs and the drugs most commonly implicated in <fc>ADR</fc> s were systemic agents such as anticancer drugs and immunosuppressants. </section> <section xml:id="jphs12160-sec-0004"> <title type="main">Conclusions > This study demonstrates that emergency hospital admissions due to <fc>ADR</fc> s are an increasing problem for the National Health Service (NHS) in England and further research is needed to discover which interventions are most likely to reduce them. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“Jphs12160-Abs-0001”> <标题类型=“main”>抽象</ title> <部分XML：ID =“JPHS12160-SEC-0001”> <标题类型=“main”>目标</标题> >以确定不良药物反应的规模（<FC> ADR </ FC>） - 相关的紧急情况从2008年到2015年英国的医院入院使用医院剧集统计（<FC> HES </ FC>）数据库。 </ p> </ section> <section XML：ID =“JPHS12160-SEC-0002”> <标题类型=“main”>方法</ title> >部分<fc> hER </ fc>数据库包含有关英格兰所有医院入学的信息。年度数据在线发布并公开可用。分析了这些医院入院数据以确定<FC> ADR </ FC> S是否有多少应急录取。国际疾病分类，第10版（<FC> ICD </ FC> -10）代码，表明药物是入院的主要原因。 </ p> </ section> <section XML：ID =“JPHS12160-SEC-0003”> <标题类型=“main”>键查找</ title> >急诊医院入学总数增加12.1％，从2008/2009年的5 010 670到2014/2015年的5 615 707。在同一时期内，由于<FC> ADR </ FC> S引起的应急入学时间增加了53.4％，从2008/2009年的6055年增加到2014/2015到92 114。这些数字表明在研究期间增加了急诊医院入学比例的增加，从2008/2009年的1.2％到2014/2015年的1.6％。 </ p> >在2014/2015年，2008/2009年的51 841 443，利用的床天数减少了7.1％。尽管这总体上减少了，但2008/2009年至947 016（2.0％），由于<FC> ADR </ FC> S由于<FC> ADR </ FC> S的床天数增加了51.5％（所有床天的1.2％）（2.0％所有床位）于2014/2015年。 </ p> >最常见的<fc> ADR </ Fc> S是由于药物和最常用于<FC> ADR </ Fc> S的药物和行为障碍是全身性药物如抗癌药物和免疫抑制剂。 </ p> </ section> <section XML：ID =“JPHS12160-SEC-0004”> <标题类型=“main”>结论</ title> >本研究表明，由于<FC>引起的紧急医院录取ADR </ FC> S是英格兰国家卫生服务（NHS）的日益增长的问题，需要进一步研究，发现哪些干预措施最有可能减少它们。 </ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35439/'>《Journal of pharmaceutical health services research:》</a> <b style="margin: 0 2px;">|</b><span>2017年第1期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Veeren Jennifer C.&option=202" target="_blank" rel="nofollow">Veeren Jennifer C.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Weiss Marjorie&option=202" target="_blank" rel="nofollow">Weiss Marjorie;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Pharmacy and PharmacologyUniversity of BathBath UK;</p> <p>Department of Pharmacy and PharmacologyUniversity of BathBath UK;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/207.html" title="药学">药学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=drug‐related side effects and adverse reactions&option=203" rel="nofollow">drug‐related side effects and adverse reactions;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hospital admissions&option=203" rel="nofollow">hospital admissions;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=international classification of diseases&option=203" rel="nofollow">international classification of diseases;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=patient admission&option=203" rel="nofollow">patient admission;</a> </p> <div class="translation"> 机译：毒品相关的副作用和不良反应;医院入学;国际疾病分类;患者入学; 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CN113158073A </span> <span> . 2021-07-23</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130501431108.html">COMPOSITION FOR PREVENTION AND/OR IMPROVEMENT OF ADVERSE DRUG REACTION, SYMPTOM ASSOCIATED WITH ADVERSE DRUG REACTION, AND/OR ADVERSE REACTION ASSOCIATED WITH MEDICAL TREATMENT</a> <b>[P]</b> . <span> 外国专利：  US2022023335A1 </span> <span> . 2022-01-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：预防和/或改善不良药物反应的组合物，与不良药物反应相关的症状，和/或与医疗相关的不良反应 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130422508794.html">METHOD OF DETECTING ADVERSE REACTION TO DRUG BASED ON RETROSPECTIVE COHORT STUDY USING ELECTRONIC MEDICAL RECORD, METHOD OF DETECTING ADVERSE REACTION TO INTERVENTION, AND METHOD OF DETECTING ADVERSE REACTION TO DRUG OR INTERVENTION BASED ON RETROSPECTIVE COHORT 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