The effect of two different doses of remifentanil on postoperative pain and opioid consumption after cardiac surgery - a randomized controlled trial

摘要

BackgroundRemifentanil, an ultra-short-acting opioid, provides intensive analgesia without prolonged respiratory depression and is widely used in cardiac surgery. Diminished dosing may also offer stable hemodynamics, even during sternotomy and sternal retraction. However, increased postoperative pain and induced opioid tolerance after remifentanil dosing during abdominal surgery was reported. We tested whether remifentanil 0.3g/kg/min infusion increased postoperative opioid consumption and pain compared to 0.1g/kg/min dosing.