Pulse pressure amplification and cardiac autonomic dysfunction in patients with type 2 diabetes mellitus.

摘要

The main aim of this cross-sectional study was to investigate the association between pulse pressure amplification (PPA) and cardiac autonomic activity (baroreflex sensitivity (BRS) and heart rate variability (HRV)) in patients with type 2 diabetes mellitus (T2DM). In addition, we examined the association between cardiac autonomic activity and central hemodynamic parameters that may affect PPA such as augmentation index (AIx), aortic stiffness (pulse wave velocity (PWV)), and common carotid artery stiffness distensibility coefficient (DC). A total of 142 patients with T2DM were included in the study. In multivariate linear regression analysis-after controlling for age, diabetes duration, height, waist circumference, aortic PWV, use of β-blockers, and BRS-PPA was associated significantly and independently with male gender (standardized regression coefficient (β)?=?0.156, p?=?0.007), aortic systolic blood pressure (β?=?-0.221, p?