Preparation of 2,5‐disubstituted pyrimidines from vinamidinium salts and synthesis of novel disulfane derivatives

Rafiee Samani Ziba; Mehranpour Abdolmohammad; Hasaninejad Alireza

摘要

Abstract > Novel pyrimidine derivatives were prepared from the reaction of 2‐substituted 1,3‐bis(dimethylamino)‐trimethinium salts with thiourea or guanidine in the presence of ethyl‐diisopropylamine in ethanol at reflux, and also some 5‐substituted pyrimidine‐2‐thiols has been used for the synthesis of novel disulfane compounds. Infrared, 1 H NMR, 13 C NMR, and mass spectral data confirm the molecular structures of the newly synthesized compounds. The ultraviolet spectral behavior of these compounds was examined in DMSO and the <fi>?</fi> <sub>max</sub> of these compounds was studied. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 在回流乙醇中的乙基二异丙胺存在下，用2-取代的1,3-双（二甲基氨基） - 三甲基盐的反应制备新的嘧啶衍生物。在回流的乙醇中，还有一些5-取代的嘧啶-2-硫醇已被用于合成新型二硫胺化合物。红外线的， 1 </ sup> H NMR， 13 </ sup> C NMR和质谱数据证实了新合成的化合物的分子结构。这些化合物的紫外光谱行为在DMSO和DMSO和 <fi>？</ fi> <sub> max </ sub> 研究了这些化合物。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34660/'>《Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry》</a> <b style="margin: 0 2px;">|</b><span>2020年第5期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rafiee Samani Ziba&option=202" target="_blank" rel="nofollow">Rafiee Samani Ziba;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mehranpour Abdolmohammad&option=202" target="_blank" rel="nofollow">Mehranpour Abdolmohammad;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hasaninejad Alireza&option=202" target="_blank" rel="nofollow">Hasaninejad Alireza;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Chemistry Faculty of SciencePersian Gulf UniversityBushehr Iran;</p> <p>Department of Chemistry Faculty of SciencePersian Gulf UniversityBushehr Iran;</p> <p>Department of Chemistry Faculty of SciencePersian Gulf UniversityBushehr Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1184.html" title="有机化学">有机化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature 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tuijian_authcolor"> . 王建华</a> <span> <a href="/journal-cn-10958/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 高等学校化学学报 </a> </span> <span> . 1995</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_tianjin-chemical-industry_thesis/0201248492433.html">含有呋喃环的2,5-二取代噁二唑类衍生物的合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘会彬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘会彬</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王帅东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王帅东</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=尚洪帅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,尚洪帅</a> <span> <a href="/journal-cn-9222/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 天津化工 </a> </span> <span> . 2014</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-19630_thesis/020222258541.html">含吡啶的2，5-二取代-1，3，4一(口惡)二唑衍生物的合成与杀菌活性</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王卫东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王卫东</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=韦佳佳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,韦佳佳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈乐&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈乐</a> <span> <a href="/conference-cn-19630/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国化工学会农药专业委员会第十三届年会 </a> <span> <span> . 2008</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312434410.html">具有生物活性的多取代-2-氨基嘧啶衍生物及其稠杂环化合物的研究（Ⅷ、Ⅸ）;Ⅷ：N'-（4,6-二取代嘧啶-2-基）-N-取代酰基硫脲的合成，晶体结构及除草活性;Ⅸ：5,7-二取代芳酰亚胺基-2H-1,2,4-噻二唑并[2,3-a]嘧啶的合成及除草活性</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王洁平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王洁平</a> <span> . 2003</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120101106592.html">2,5-二取代-1,2,4噻二唑-3（2H）-硫酮、衍生物及其合成方法</a> <b>[P]</b> . <span> 中国专利： CN110204508A </span> <span> . 2019-09-06</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120112919537.html">用于治疗病毒感染的2,6-二甲基-N-((吡啶-4-基)甲基)咪唑并1,2-b哒嗪-8-胺和2,5-二甲基-N-(吡啶-4-基)甲基吡唑并1,5-a嘧啶-7-胺衍生物</a> <b>[P]</b> . <span> 中国专利： CN112969703A </span> <span> . 2021-06-15</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130456962198.html">DERIVATIVES OF N-(2,4- OR 2,5-DISUBSTITUTED TETRAHYDROFURYLALKYL)-N-(PHENYLETHYL--OL)-AMINE IN RACEMIC OR ENANTIOMERIC FORM, OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION</a> <b>[P]</b> . <span> 外国专利：  RU2060252C1 </span> <span> . 1996-05-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：N-（2,4-或2,5-二取代的四氢呋喃烷基）-N-（苯甲基-OL）-胺的衍生物或对映体形式，或它们的药理学上可接受的盐的衍生物，其合成方法和药物成分 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130470353983.html">Polypeptide derivatives containing 2,5-disubstituted 5-amino-4-hydroxypentansyrerester, 2,5-disubstituted 5-amino-4-hydroxypentansyrederivater for use as intermediates and stereoselective processes for the preparation of these</a> <b>[P]</b> . <span> 外国专利：  DK379186A </span> <span> . 1987-04-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：含有2,5-二取代的5-氨基-4-羟基戊二酸酯，2,5-二取代的5-氨基-4-羟基戊二酮酯衍生物的多肽衍生物，用作制备这些中间体的中间体和立体选择方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130455235552.html">2,5 - Disubstituted pyrazine - derivatives, pyrimidine - derivatives and liquid crystals</a> <b>[P]</b> . <span> 外国专利：  DE68926635T2 </span> <span> . 1997-01-02</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：2,5-二取代的吡嗪-衍生物，嘧啶-衍生物和液晶 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div 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