Synthesis, Characterization, and Biological Evaluation of Novel 3-(4-Chlorophenyl)-2-(substituted)quinazolin-4(3H)-one Derivatives as Multi-target Anti-inflammatory Agents

摘要

A novel class of 3-(4-chlorophenyl)-2-(substituted)quinazolin-4(3H)-one derivatives were synthesized, and the structure of synthesized compounds was characterized by IR, H-1 NMR, and mass spectroscopy. The newly synthesized compounds (4a-g and 6a-g) were tested for their in vitro cyclooxygenase (COX) inhibition activity. The compounds have inhibitory profile against both COX-1 and COX-2, and some of the compounds are found to be selective against COX-2. The compound 6g showed distinct inhibitory activity on COXs. The synthesized compounds were evaluated for their potential anti-inflammatory activity as inhibitors of the proinflammatory cytokines IL-6. Compounds 4d-g showed the highest level of inhibition among all the tested compounds. Thus, our data suggested that these compounds may represent a new class of potent anti-inflammatory agents.