Green approach for the synthesis of 3‐methyl‐1‐phenyl‐4‐((2‐phenyl‐1H‐indol 3‐yl)methylene)‐1H‐pyrazole‐5(4H)‐ones and their DNA Cleavage, antioxidant, and antimicrobial activities

机译：用于合成3-甲基-1-苯基-4-（（2-苯基-1H- Indol 3-Y1）亚甲基）-1H-吡唑-5（4H）的绿色方法及其DNA裂解，抗氧化剂和抗菌活性

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Abstract > 3‐Methyl‐1‐phenyl‐4‐((2‐phenyl‐1 H ‐indol‐3‐yl)methylene)‐1 H ‐pyrazol‐5(4H)‐ones (5a‐i) was prepared by the condensation reaction of different 3‐formyl‐2‐phenylindole derivatives (2a‐i) and 3‐methyl‐1‐phenyl‐2‐pyrazoline‐5‐one in quantitative yield by applying various green synthetic methods as grinding, microwave irradiation using different catalysts under solvent‐free mild reaction conditions with high product yields. The structures of the synthesized compounds were characterized on the basis of elemental analysis, infrared, 1 HNMR, 13 C NMR, and mass spectral data. The synthesized compounds were screened for free radical scavenging, antimicrobial, and DNA cleavage activities. Most of the tested compounds belonging to the 3‐methyl‐1‐phenyl‐4‐((2‐phenyl‐1 H ‐indol‐3‐yl)methylene)‐1 H ‐pyrazol‐5(4H)‐ones series exhibited promising activities. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 3-甲基-1-苯基-4 - （（2-苯基-1 h </ i> -indol-3-yl）亚甲基）-1 h </ i> 通过不同的3-甲酰基-2-苯基吲哚衍生物（2a-1）和3-甲基-1-苯基-2-吡唑啉-5-吡唑啉-5-吡唑啉-5-制备 - 戊唑-5（4H） - 酮（5A-1）制备通过将各种绿色合成方法施加作为研磨，微波照射在不含产物产率的溶剂的温和反应条件下使用不同的催化剂来定量产率。合成化合物的结构在基于元素分析，红外线的基础上表征， 1 </ sup> HNMR， 13 </ sup> C NMR和质谱数据。筛选合成的化合物以自由基清除，抗微生物和DNA切割活性。属于3-甲基-1-苯基-4-（（2-苯基-1 h </ i> -indol-3-yl）亚甲基）-1 h </ i> -Pyrazol-5（4H）-Ones系列表现出有希望的活动。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34660/'>《Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry》</a> <b style="margin: 0 2px;">|</b><span>2019年第12期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Modi Madhuri&option=202" target="_blank" rel="nofollow">Modi Madhuri;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jain Meenakshi&option=202" target="_blank" rel="nofollow">Jain Meenakshi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Center of advance studies Department of chemistryUniversity of RajasthanJaipur India;</p> <p>Center of advance studies Department of chemistryUniversity of RajasthanJaipur India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1184.html" title="有机化学">有机化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" 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href="/academic-conference-cn_meeting-20315_thesis/0202274734.html">N-(3-氰基-1-(2,6-二氯-4-(三氟甲基)苯基)-1H-吡唑-5-基菊酰胺类化合物的合成及生物活性</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵金浩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵金浩</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程敬丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,程敬丽</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=魏方林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,魏方林</a> <span> <a href="/conference-cn-20315/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第三届“农药与环境安全”国际学术研讨会暨第七届“植物化学保护和全球法律一体化”国际研讨会 </a> <span> <span> . 2007</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031395743.html">1-(4-溴苯基)-2-(2-甲基-4-硝基-1H-咪唑-1-基)乙酮肟衍生物的合成及其生物活性研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭凤娇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 郭凤娇</a> <span> . 2015</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061201118154.html">(S)-2-氨基-3-(4-(2-氨基-6-((R)-1-(4-氯-2-(3-甲基-1H-吡唑-1-基)苯基)-2,2,2-三氟乙氧基)-嘧啶-4-基)苯基)丙酸乙酯的固体形式及其使用方法</a> <b>[P]</b> . <span> 中国专利： CN101809018B </span> <span> . 2013.02.06</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120106016517.html">(S)-2-氨基-3-(4-(2-氨基-6-((R)-1-(4-氯-2-(3-甲基-1H-吡唑-1-基)苯基)-2,2,2-三氟乙氧基)-嘧啶-4-基)苯基)丙酸乙酯的固体形式及其使用方法</a> <b>[P]</b> . <span> 中国专利： CN101809018A </span> <span> . 2010-08-18</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130411287774.html">METHYL 1-ARYL-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-2,4,5,6-TETRAHYDRO-5'H-SPIROINDOLE-7,4'-ISOXAZOLE-7a(1H)-CARBOXYLATES, METHYL 1-ARYL-(1'-PHENYL AND 1'-BENZYL)-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-1',2,4,5,5',6-HEXAHYDROSPIROINDOLE-7,4'-PYRAZOLE-7a(1H)-CARBOXYLATES AND METHYL 1'-ARYL-3'-HYDROXY-1,2',3,4'-TETRAOXO-6'-PHENYL-1,2',3,4',5',6'-HEXAHYDROSPIROINDENE-2,7'-INDOLE-7a'(1'H)-CARBOXYLATES, DEMONSTRATING ANALGESIC ACTIVITY AND METHOD FOR OBTAINING THEREOF</a> <b>[P]</b> . <span> 外国专利：  RU2577528C2 </span> <span> . 2016-03-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：甲基1-ARYL-3-羟基-3'-甲基-2,4,5'-三氧-6-苯基-2,4,5,6-四羟基-5'H-螺[吲哚-7,4'-异恶唑] -7a（1H）-羧酸盐，甲基1-芳基-（1'-苯酚和1'-苄基）-3-羟基-3'-甲基-2,4,5'-三氧-6-苯酚-1 '，2,4,5,5'，6-己基螺[吲哚-7,4'-吡唑] -7a（1H）-羧酸盐和甲基1'-ARYL-3'-羟基-1,2'，3， 4'-TETRAOXO-6'-苯基-1,2'，3,4'，5'，6'-六羟基螺[INDENE-2,7'-吲哚] -7a'（1'H）-羧酸盐，证明镇痛剂的活动和方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130427911778.html">4 - (3 - ((4 - (1 - methyl - 5 - 1H pyrazole - il) phenyl thio} phenyl) - tetrahydro 2H - carboxamide and Piran - 4 - 4 - (3 - ((3-fluoro-4 - (1 - methyl - 5 - 1H pyrazole - il) phenyl) phenyl thio} - tetrahydro 2H - piran - 4 - carboxamide, useful as Medicines for the treatment of diseases that includes</a> <b>[P]</b> . <span> 外国专利：  CO6180447A2 </span> <span> . 2010-07-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：4-（3-（（（4-（1-甲基-5-1H吡唑-il）苯基]硫基}苯基）-四氢2H-羧酰胺和Piran-4-4-（3-（（3-氟-4- （1-甲基-5-1H吡唑-il）苯基）苯基]硫基}-四氢2H-吡兰-4-羧酰胺，可用作治疗疾病的药物，包括 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130425496210.html">4-methylbenzenesulfonate 6 - methyl - 5 - (1 - methyl - 5 - 1H pyrazole - yl) - N - 5 - (methylsulfonyl) pyridin-2-yl methyl - 2 - oxo - 1 - 3 - (trifluoromethyl) phenyl - 3 - 1.2 - dihidropiridin - carboxamide crystalline and modification thereof, Pharmaceutical compositions containing them and Use thereof in the treatment of illness</a> <b>[P]</b> . <span> 外国专利：  AR075523A1 </span> <span> . 2011-04-06</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：4-甲基苯磺酸盐6-甲基-5-（1-甲基-5-1H吡唑基）-N-[5-[（（甲基磺酰基）吡啶-2-基]甲基]]-2-羰基-1-[3-（ [三氟甲基）苯基]-3-1.2-二hiridiridin-羧酰胺晶体及其修饰，含有它们的药物组合物及其在疾病治疗中的用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" 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