A study of the association between UGT1A1*28 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer

摘要

Introduction: The transcriptional activity of the UGT1A1 gene is modulated by a variable number of repetitions of the dinucleotide (TA) within its promoter region. By comparison to the most common allele (TA) 6 (UGT1A1* 1), decreased activity is observed with increasing TA repetitions. The aim of this study was to determine whether the presence of the variant allele UGT1A1* 28, harbouring seven TA repetitions, (TA) 7, in the homozygous state, is associated with precancerous colonic lesions and/or with specific colorectal cancer characteristics.