Assessment of treatment factors and clinical outcomes in cervical cancer in older women compared to women under 65 years old

摘要

ObjectiveThis study aims to understand the treatment patterns and clinical outcomes of older women with cervical cancer compared to younger women. MethodsWomen undergoing care for cervical cancer between 2000 and 2013 at two academic institutions were identified. The cohort of older patients was defined as >65?years old at diagnosis. Patient charts were retrospectively reviewed, and clinical variables were extracted. Fisher's exact tests, logistic regression, and Kaplan-Meier analyses were performed. ResultsFrom 2000 to 2013 1119 women with cervical cancer were identified. Of these, 191 (17.0%) were >65?years old at the time of diagnosis. Older women were more likely to present with higher stage disease (p? ?65 (HR 1.76, 95%CI 1.30–2.40), stage (HR 2.77, 95%CI 2.40–3.21), and ever undergoing surgery (HR 0.60, 95%CI 0.44–0.82) as independently associated with overall survival. ConclusionsWomen over age 65 with cervical cancer are less likely to undergo surgical management and were observed to have a decreased overall survival, even when controlling for use of surgery and stage of disease.