Critical Role of CD6(high)CD4(+) T Cells in Driving Th1/Th17 Cell Immune Responses and Mucosal Inflammation in IBD

摘要

Background and Aims CD6 is a crucial regulator of T cell activation and is implicated in the pathogenesis of multiple autoimmune diseases. ALCAM is the first identified endogenous ligand of CD6. We sought to investigate potential roles of CD6 in regulating intestinal mucosal inflammation in inflammatory bowel disease [IBD].