Cost comparison of commonly used?postoperative topical ophthalmic?antibiotics

摘要

Purpose To provide information on the actual fill level and cost of燾urrently available antibiotic drops used perioperatively. Design Prospective laboratory investigation. Setting Robert Cizik Eye Clinic, Houston, Texas USA. Methods The following 9 medications were tested: moxifloxacin, gatifloxacin?branded and generic), besifloxacin, levofloxacin, ciprofloxacin, ofloxacin, trimethoprim/polymyxin B, tobramycin, and gentamicin. Actual bottle-fill volume and number of drops per bottle were measured using 10 bottles of each formulation. The percentage of the bottle used and the perioperative cost (using average wholesale price) were calculated for 3 times a day and 4 times a day dosing for 7-day, 10-day, and 14-day courses. Formulations were compared using 1-way analysis of variance with Tukey multiple comparisons. Results For medications with sticker volumes of at least 5爉L, all but 2 medications (ofloxacin, 4 times a day for 14燿ays; gentamicin, 4 times a day for 14燿ays) covered 2 perioperative courses. Besifloxacin had a fill volume less than the爏ticker volume.燭he most cost-effective perioperative antibiotic prophylaxis was trimethoprimpolymyxin B (4 times a day: $12.87 for 7-day, 10-day, and 14-day courses, and $46.88 for 4-day course; 3 times a day: $12.87 for 7-day, 10-day, and 14-day courses). Conclusions Most antibiotics had an actual fill volume greater than sticker volume, which is a sufficient drug regimen for 2 perioperative courses. The costs of common postoperative topical antibiotic regimens vary widely depending on the drug and dosing regimen. Cost considerations for perioperative antibiotics will be increasingly important because the number of cataract surgeries爄s expected爐o increase with the growing and aging population.