Synthesis of 2-(1-oxo-2,3-dihydro-1H-pyrrolizin-2-yl)-2-(aryl)acetonitrile derivatives via Michael addition of trimethylsilyl cyanide

摘要

Several 2-aryl-2-(1-oxo-2,3-dihydro-1H-pyrrolizin-2-yl)acetonitrile derivatives were synthesised by Michael addition of (E)-2-arylidene-2,3-dihydro-1H-pyrrolizin-1-ones with trimethylsilyl cyanide in the presence of tetrabutylammonium fluoride in moderate yields. The structures of all of the products were fully characterised by NMR, IR and high-resolution mass spectrometry, together with X-ray crystallographic analysis.