Possible predictors of age at illness onset and illness duration in a cohort study comparing younger adults and older major a?ective patients

摘要

Major aiective conditions including major depressive disorder (MDD) and bipolar disorder (BD) are associated with signicant disability and psychosocial impairment over the life course (Rush, 2003; Andlin-Sobocki etal.,2005). Althoughthese invalidatingconditions are associated with higher medical costs, morbidity, and mortality (Katon and Sullivan, 1990), they are often not adequately recognized or diagnosed due to the complexity and heterogeneity of their clinical presentations