AMIDE BOND FORMATION OF SIALIC ACID IN OLIGOSACCHARIDE WITHOUT PROTECTING GROUP

摘要

With the aim of preparing glycan-linked antibody-drug conjugates, we investigated the feasibility of amide bond formation at the carboxylic acid of sialic acid in a protection-free oligosaccharide. The use of a phosphonium salt-based reagent, PyBOP, gave the desired compound. Bio-orthogonal functional groups were conjugated at the carboxylic acid site of sialic acid in glycans.