DIASTEREOSELECTIVITY IN THE METHYLATION AND REDUCTION OF 3-ARYL-3a,4,5,6,7,7A-HEXAHYDRO-1,2-BENZISOXAZOL-4-ONES

摘要

Various 3-aryl-3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-4-ones were methylated at 3a-positions and reduced by NaBH_4 to afford the corresponding 3a,4-cis-3a,7a-cis-3a-methyl-3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-4-ols were easily converted to the corresponding 2-aroyl-2-methylcyclohexane-1,3-diols by catalytic hydrogenation with Raney Ni.