SYNTHESIS, TRANSFORMATION OF 3-[(4-ARYLTHIAZOL-2-YL)-(p-TOLYL)AMINO]PROPANOIC ACIDS, BIS(THIAZOL-5-YL)PHENYL-, BIS(THIAZOL-5-YL)METHANE DERIVATIVES, AND THEIR ANTIMICROBIAL ACTIVITY

摘要

Bis(thiazol-5-yl)phenyl- and bis(thiazol-5-yl)methanes were synthesized by the reaction of 2,4-disubstituted thiazoles with aromatic aldehydes or formaldehyde. In addition, modification of the carboxyl group of the molecule was carried out. The reactions afforded compounds bearing various heterocyclic fragments. All the synthesized compounds were tested for their effect on Escherichia coli, Staphylococcus aureus and Mycobacterium luteum bacteria and Aspergillus niger and Candida tenuis fungi strains. Some of them exhibited antibacterial activity against test-culture Mycobacterium luteum.