A SYNTHESIS OF HEXAHYDRO-H-OXAZOLOP[3,4-a]PYRAZIN-3-ONES FROM FUSED AZIRIDINES

摘要

The piperazine ring is a common structural component of a large variety of biologically active small molecules. While a number of methods to prepare simple piperazine rings are known, the methods available for the synthesis of fused-ring piperazines are lacking. We report here a method for the synthesis of novel fused-ring piperazines through reaction with fused-ring aziridines followed by a ring closure to form the fused-ring piperazine system. The dependence of the reaction on the stereochemistry of the system has also been studied.