SYNTHESIS OF PYRROLO[2,3-d]PYRIMIDINE ANALOGUES:'PYRIDINE RING' ANALOGUES OF PEMETREXED

摘要

Two analogues of pemetrexed with its phenyl ring replaced with pyridine ring as novel anticancer agents were synthesized. Preliminary in vitro evaluation indicated that replacement of the phenyl moiety of pemetrexed hy the pyridine ring with the 6-5 bicyclic ring system showed low cytotoxicity, that departs from the findings with antifolates bearing 6-6 bicyclic ring system.