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Efficacy and Safety of Deep Brain Stimulation in Tourette SyndromeThe International Tourette Syndrome Deep Brain Stimulation Public Database and Registry

机译:温室刺激在Tourette Syndromethe国际Tourette综合征深脑刺激公共数据库和注册表中的疗效和安全性

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摘要

P ??.001). The mean (SD) motor tic subscore improved from 21.00 (3.72) at baseline to 12.91 (5.78) after 1 year ( P ??.001), and the mean (SD) phonic tic subscore improved from 16.82 (6.56) at baseline to 9.63 (6.99) at 1 year ( P ??.001). The overall adverse event rate was 35.4% (56 of 158 patients), with intracranial hemorrhage occurring in 2 patients (1.3%), infection in 4 patients with 5 events (3.2%), and lead explantation in 1 patient (0.6%). The most common stimulation-induced adverse effects were dysarthria (10 [6.3%]) and paresthesia (13 [8.2%]). Conclusions and Relevance ?Deep brain stimulation was associated with symptomatic improvement in patients with Tourette syndrome but also with important adverse events. A publicly available website on outcomes of DBS in patients with Tourette syndrome has been provided.
机译:p?& 001)。 平均(SD)电机TIC子核核心从21.00(3.72)以1年后的基线增加到12.91(5.78),并且平均(SD)PHONIC TIC子座从16.82(6.56)改善 在1年(p≤001)的基线至9.63(6.99)。 总不良事件率为35.4%(56名患者中的56名中),2例患者发生颅内出血(1.3%),4例患者的感染(3.2%),1例患者铅脱盐(0.6%)。 最常见的刺激诱导的不良反应是讨厌的(10 [6.3%])和感觉(13 [8.2%])。 结论和相关性?深脑刺激与Tourette综合征患者的症状性改善有关,但也具有重要的不良事件。 提供了在Tourette综合征患者患者中公开可用的DBS结果网站。

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  • 来源
    《JAMA neurology》 |2018年第3期|共7页
  • 作者单位

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

    Parkinson’s Disease Center and Movement Disorders Clinic Baylor College of Medicine Houston Texas;

    Yale Child Study Center Yale University School of Medicine New Haven Connecticut;

    Tourette’s Syndrome and Movement Disorders Center Galeazzi Hospital Milan Italy;

    Neurosurgical Department Isituto Ortopedico Galeazzi Milan Italy;

    Department of Functional Neurosurgery Beijing Neurosurgical Institute Capital Medical University;

    Department of Psychiatry and Psychotherapy University of Cologne Cologne Germany;

    Department of Psychiatry and Psychotherapy University of Cologne Cologne Germany;

    Department of Psychiatry and Psychotherapy University of Cologne Cologne Germany;

    Sobell Department of Motor Neuroscience University College London Institute of Neurology London;

    Sobell Department of Motor Neuroscience University College London Institute of Neurology London;

    Sobell Department of Motor Neuroscience University College London Institute of Neurology London;

    Sobell Department of Motor Neuroscience University College London Institute of Neurology London;

    Sobell Department of Motor Neuroscience University College London Institute of Neurology London;

    Queensland Brain Institute University of Queensland Brisbane Queensland Australia;

    Queensland Brain Institute University of Queensland Brisbane Queensland Australia;

    Department of Neurosurgery Center for Neuromodulation New York University Langone Medical Center;

    Department of Neurosurgery Center for Neuromodulation New York University Langone Medical Center;

    Department of Neurology The Permanente Medical Group (Kaiser Permanente Northern California);

    Department of Medicine Pamela Youde Nethersole Eastern Hospital Hong Kong SAR China;

    Department of Neurology University of California San Francisco;

    Department of Stereotaxy and Functional Neurosurgery University Hospital Cologne Cologne Germany;

    The French National Institute of Health and Medical Research U 1127 The National Center for;

    Assistance Publique–H?pitaux de Paris Personalised Neurology and Psychiatry University Department;

    Institut du Cerveau et de la Mo?lle Epinière The French National Institute of Health and Medical;

    Service de Neurologie Centers for Clinical Investigation 1402 Centre Hospitalier Universitaire de;

    Department of Neurology Mayo Clinic Rochester Minnesota;

    Department of Neurosurgery Maastricht University Medical Centre Maastricht the Netherlands;

    Department of Neurosurgery National Hospital Organization Nara Medical Center Nara Japan;

    Maastricht University Medical Center Maastricht the Netherlands;

    Emory University Atlanta Georgia;

    Division of Movement Disorders Department of Neurology University of Alabama at Birmingham;

    Toronto Western Hospital Division of Neurosurgery University of Toronto Toronto Ontario Canada;

    School of Medicine Case Western Reserve University Cleveland Ohio;

    Department of Neurology and Neurosurgery Johns Hopkins University Baltimore Maryland;

    Department of Neurology and Neurosurgery Johns Hopkins University Baltimore Maryland;

    Department of Neurology The Ohio State University Wexner Medical Center Columbus;

    Division of Neurology Centre Hospitalier Universitaire de Grenoble Grenoble France;

    Department of Neurology Indiana University School of Medicine Indianapolis;

    Neuromodulation Research Center Department of Neurology University of Minnesota Minneapolis;

    Department of Functional Neurosurgery Beijing Tiantan Hospital Capital Medical University;

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

    Center for Movement Disorders and Neurorestoration Department of Neurosurgery University of;

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

    Brain Map Lab Center for Movement Disorders and Neurorestoration Department of Neurology;

    Center for Movement Disorders and Neurorestoration Department of Neurology University of Florida;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    gilles de la tourette syndrome; deep brain stimulation;

    机译:Tourette综合征的吉尔斯;深脑刺激;

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