The impact of resilience and subsequent stressful life events on MDD and GAD

Sheerin Christina M.; Lind Mackenzie J.; Brown Emily A.; Gardner Charles O.; Kendler Kenneth S.; Amstadter Ananda B.

摘要

Background >There remains a dearth of research examining the “buffering” effect of resilience, wherein resilience at one point in time would be expected to protect an individual against development of psychopathology following future adverse life events. </section> <section xml:id="da22700-sec-0020"> <title type="main">Methods > Using longitudinal data from an epidemiological twin sample ( N ?=?7463), this study tested whether resilience would act as a buffer for stressful life events (SLEs) against risk for major depressive disorder (MDD) and generalized anxiety disorder (GAD). Resilience, demographics, and psychopathology were measured at Time 1 and recent SLEs and current MDD and GAD were measured at Time 2. </section> <section xml:id="da22700-sec-0030"> <title type="main">Results >Final models, controlling for demographic covariates and Time 1 diagnosis, examined the impact of Time 1 resilience, recent SLEs, their interaction, and a three‐way interaction adding sex on MDD and GAD. </section> <section xml:id="da22700-sec-0040"> <title type="main">Conclusions >The pattern of findings was the same for MDD and GAD, wherein main effects and two‐way interactions of resilience and SLEs were significant, such that greater resilience was protective even in the context of high numbers of past‐year SLEs. The three‐way interaction was not significant, suggesting that the relationship between SLEs and resilience on psychopathology was the same for both men and women. Findings support the conceptualization of resilience as a buffer against the impact of future life stressors on common internalizing psychopathology. Longitudinal designs and trajectory‐based st </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <第XML：ID =“da22700-ec-sec-0010”> <标题类型=“main”>背景</ title> >仍然存在缺乏研究检查弹性的“缓冲”效应，其中预期在未来不良生活事件发生后的一个时间点的弹性抵御心理病理学的发展。</ p> </段> <章节XML：ID =“DA22700 -sec-0020“> <标题类型=”main“>方法</ tits> >使用来自流行病学双胞胎样品的纵向数据（ n </ i>？=？7463），这项研究检测了韧性将作为压力生活事件（SLE）的缓冲区免受重大抑郁症（MDD）和广义焦虑症（GAD）的风险。在时间1和最近的SLES和当前MDD和GAD时测量弹性，人口统计学和精神病理学在时间2中测量2. </ p> </ section> <章节XML：ID =“DA22700-SEC-0030”> <标题类型=“主要”>结果</ title> >最终模型，控制人口调节器和时间1诊断，检查了时间1个弹性，最近的斯特雷斯，他们的互动，以及在MDD上添加性别的三元互动。 gad。</ p> </ section> <section xml：id =“da22700-sec-0040”> <标题类型=“main”>结论</ title> > MDD的结果模式是相同的GAD，其中弹性和SLE的主要效果和双向相互作用是显着的，使得即使在高位过去年度股票的背景下，也是更大的弹性是保护性的。三向互动并不重要，这表明男性和女性对精神病理学的股票和恢复性之间的关系是相同的。调查结果支持对缓冲器的概念化，以防止未来生命压力源对常见的内化心理病理学的影响。纵向设计和基于轨迹的ST </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sheerin Christina M.&option=202" target="_blank" rel="nofollow">Sheerin Christina M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lind Mackenzie J.&option=202" target="_blank" rel="nofollow">Lind Mackenzie J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brown Emily A.&option=202" target="_blank" rel="nofollow">Brown Emily A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gardner Charles O.&option=202" target="_blank" rel="nofollow">Gardner Charles O.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kendler Kenneth S.&option=202" target="_blank" rel="nofollow">Kendler Kenneth S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Amstadter Ananda B.&option=202" target="_blank" rel="nofollow">Amstadter Ananda B.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University School of MedicineRichmond VA USA;</p> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University School of MedicineRichmond VA USA;</p> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University School of MedicineRichmond VA USA;</p> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University School of MedicineRichmond VA USA;</p> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University School of MedicineRichmond VA USA;</p> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University School of MedicineRichmond VA USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anxiety&option=203" rel="nofollow">anxiety;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=depression&option=203" rel="nofollow">depression;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=life stress&option=203" rel="nofollow">life stress;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=longitudinal studies&option=203" rel="nofollow">longitudinal studies;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=psychological&option=203" rel="nofollow">psychological;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=resilience&option=203" rel="nofollow">resilience;</a> </p> <div class="translation"> 机译：焦虑;抑郁症;生命压力;纵向研究;心理学;弹性; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div 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