A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress

Wolf Erika J.; Miller Mark W.; Sullivan Danielle R.; Amstadter Ananda B.; Mitchell Karen S.; Goldberg Jack; Magruder Kathryn M.

摘要

Background >To examine shared genetic and environmental risk factors across PTSD symptoms and resilience. </section> <section xml:id="da22712-sec-0020"> <title type="main">Methods >Classical twin study of 2010–2012 survey data conducted among 3,318 male twin pairs in the Vietnam Era Twin Registry. Analyses included: (a) estimates of genetic and environmental influences on PTSD symptom severity (as measured by the PTSD Checklist) and resilience (assessed with the Connor‐Davidson Resilience Scale‐10); (b) development of a latent model of traumatic stress, spanning both PTSD and resilience; and (c) estimates of genetic and environmental influences on this spectrum. </section> <section xml:id="da22712-sec-0030"> <title type="main">Results > The heritability of PTSD was 49% and of resilience was 25%. PTSD and resilience were correlated at r ?=?–.59, and 59% of this correlation was attributable to a single genetic factor, whereas the remainder was due to a single non‐shared environment factor. Resilience was also influenced by common and unique environmental factors not shared with PTSD, but there was no genetic factor specific to resilience. Confirmatory factor analysis supported the Development of a revised phenotype reflecting the broader dimension of traumatic stress, with biometric models suggesting increased heritability (66%) of this spectrum compared to PTSD or resilience individually. </section> <section xml:id="da22712-sec-0040"> <title type="main">Conclusions >Genetic factors contribute to a single spectrum of traumatic stress reflecting resilience at one end and high symptom severity at the other. This carries implications for phenotype refineme </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <第XML：ID =“da22712-sec-0010”> <标题类型=“main”>背景</ title> >检查共享遗传和患有PTSD症状和恢复力的环境风险因素。</ p> </ section> <section xml：id =“da22712-sec-0020”> <标题类型=“main”>方法</ title> >古典双胞胎研究2010-2012 2010年 - 2010年的调查数据在越南时代双人队登记处的3,318名男性双胞胎对中进行。分析包括：（a）遗传和环境影响对应激病症状严重程度的估计（按PTSD清单核对表）和弹性（用Connor-Davidson Resicience Scale-10评估）; （b）开发创伤压力潜在模型，涵盖可击陷和弹性; （c）对该频谱的遗传和环境影响的估计。</ p> </ section> <section xml：id =“da22712-sec-0030”> <标题类型=“main”>结果</ title> < p> PTSD的遗传性为49％，韧性为25％。 PTSD和弹性在 R </ i>？=？ - 。59和59％的这种相关性可归因于单一的遗传因素，而剩余部分是由于单一的非共用环境因素。弹性也受到不与应激障碍共享的共同和独特的环境因素的影响，但没有特异性的遗传因素是恢复力。确认因子分析支持开发经过修订的表型，反映创伤应激的更广泛尺寸，生物识别模型表明与单独的PTSD或弹性相比，这种光谱的可遗传性（66％）。 </ p> </ section> <section XML：ID =“DA22712-SEC-0040”> <标题类型=“main”>结论</标题> >遗传因子有助于一种反射弹性的创伤应力在一端和高症症状严重程度。这对表型培养材料进行了影响 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wolf Erika J.&option=202" target="_blank" rel="nofollow">Wolf Erika J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miller Mark W.&option=202" target="_blank" rel="nofollow">Miller Mark W.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sullivan Danielle R.&option=202" target="_blank" rel="nofollow">Sullivan Danielle R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Amstadter Ananda B.&option=202" target="_blank" rel="nofollow">Amstadter Ananda B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mitchell Karen S.&option=202" target="_blank" rel="nofollow">Mitchell Karen S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Goldberg Jack&option=202" target="_blank" rel="nofollow">Goldberg Jack;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Magruder Kathryn M.&option=202" target="_blank" rel="nofollow">Magruder Kathryn M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>National Center for PTSDVA Boston Healthcare SystemBoston MA USA;</p> <p>National Center for PTSDVA Boston Healthcare SystemBoston MA USA;</p> <p>National Center for PTSDVA Boston Healthcare SystemBoston MA USA;</p> <p>Department of Psychiatry and School of MedicineVirginia Commonwealth UniversityRichmond VA USA;</p> <p>National Center for PTSDVA Boston Healthcare SystemBoston MA USA;</p> <p>Seattle Epidemiologic Research and Information CenterVA Puget Sound Health Care SystemSeattle WA USA;</p> <p>Department of Psychiatry and Behavioral SciencesMedical University of South CarolinaCharleston SC USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=genetic&option=203" rel="nofollow">genetic;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=PTSD&option=203" rel="nofollow">PTSD;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=resilience&option=203" rel="nofollow">resilience;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=traumatic stress&option=203" rel="nofollow">traumatic stress;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=twins&option=203" rel="nofollow">twins;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vietnam Era Twin Registry&option=203" rel="nofollow">Vietnam Era Twin Registry;</a> </p> <div class="translation"> 机译：遗传;PTSD;弹性;创伤应力;双胞胎;越南时代双人登记处; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195430.html">A classical twin study of PTSD symptoms and resilience: Evidence for a single spectrum of vulnerability to traumatic stress</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wolf Erika J.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wolf Erika J.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miller Mark W.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Miller Mark W.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sullivan Danielle R.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sullivan Danielle R.,</a> <a href="/journal-foreign-32884/" target="_blank" rel="nofollow" class="tuijian_authcolor">Depression and anxiety .</a> <span>2018</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：PTSD症状和恢复力的古典双胞胎研究：对创伤应力的单一脆弱性的证据</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704011212846.html">Low specificity of symptoms on the post-traumatic stress disorder (PTSD) symptom scale: a comparison of individuals with PTSD, individuals with other anxiety disorders and individuals without psychopathology.</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Engelhard IM&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Engelhard IM,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arntz A&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Arntz A,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=van-den-Hout MA&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">van-den-Hout MA </a> <a href="/journal-foreign-30557/" target="_blank" rel="nofollow" class="tuijian_authcolor">The British journal of clinical psychology .</a> <span>2007</span><span>,第Pta4期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：创伤后应激障碍（PTSD）症状量表的症状特异性较低：患有PTSD的个体，患有其他焦虑症的个体和没有精神病理学的个体的比较。</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024672274.html">EFFECTS OF MINDFULNESS-BASED STRESS REDUCTION (MBSR) ON PTSD SYMPTOMS AND BRAIN RESPONSE TO TRAUMATIC REMINDERS OF COMBAT IN OPERATION ENDURING FREEDOM/OPERATION IRAQI FREEDOM (OEF/OIF) COMBAT VETERANS WITH POSTTRAUMATIC STRESS DISORDER (PTSD)</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bremner J. 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tuijian_authcolor"> . 龙小芳</a> <span> . 2008</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130404026637.html">DNA Methylation Landscapes of Post-Traumatic Stress Disorder (PTSD) Susceptibility and Resilience and Novel Therapeutics of PTSD Derived Thereof</a> <b>[P]</b> . <span> 外国专利：  US2019038587A1 </span> <span> . 2019-02-07</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：创伤后应激障碍（PTSD）易感性和适应力的DNA甲基化景观及由此衍生的PTSD的新疗法 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130425493644.html">Use of a compound inhibitor of the reuptake of serotonin to decrease adverse effects associated with traumatic memories or to prevent the development of post-traumatic Stress Disorder (PTSD) occurred after a traumatic Event</a> <b>[P]</b> . <span> 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