A randomized controlled pilot trial of vilazodone for adult separation anxiety disorder

Schneier Franklin R.; Moskow Danielle M.; Choo Tse‐Hwei; Galfalvy Hanga; Campeas Raphael; Sanchez‐Lacay Arturo

摘要

Background > Separation anxiety disorder was recently recognized by fifth edition of the Diagnostic and Statistical Manual of Mental Disorders as a diagnosis in adults, but no publications to date have characterized a sample of patients seeking treatment for adult separation anxiety disorder (ASAD) or assessed treatment efficacy. We hypothesized that vilazodone, a selective serotonin reuptake inhibitor (SSRI) and serotonin 1a (5HT1 <sub>a</sub> ) receptor partial agonist, would have efficacy in ASAD, because SSRIs have appeared efficacious in children with mixed diagnoses including separation anxiety disorder and in animal models of separation anxiety. </section> <section xml:id="da22693-sec-0020"> <title type="main">Methods > In this pilot study, 24 adults (ages 18–60) with a principal diagnosis of ASAD were randomized to 12?weeks of double‐blind treatment with vilazodone ( n ?=?13) or placebo ( n ?=?11). Outcome was assessed by an independent evaluator and self‐ratings, and analyzed with mixed effect models. </section> <section xml:id="da22693-sec-0030"> <title type="main">Results > This sample was predominantly female (67%), with comorbid psychiatric disorders (58%), and adult onset of separation anxiety disorder (62%). Response rates at week 12 did not differ significantly between groups. Across all time points, the vilazodone group evidenced greater improvement on the Structured Clinical Interview for Separation Anxiety Symptoms ( P ?=?.026) and the Quality of Life Enjoyment and Satisfaction Questionnaire ( P? =?.011), and trends toward greater improvemen </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <部分XML：ID =“da22693-ec-0010”> <标题类型=“main”>背景</ title> >最近分离焦虑症第五版精神障碍的第五版诊断和统计手册作为成人的诊断，但迄今为止没有出版物表征了寻求成人分离焦虑症（ASAD）或评估治疗疗效治疗的患者样本。我们假设Vilazodone，一种选择性血清素再摄取抑制剂（SSRI）和血清素1a（5ht1 <sub> A </ sub>）受体部分激动剂在亚亚述中具有疗效，因为SSRIS在混合诊断的儿童中似乎有效，包括分离焦虑分离焦虑的紊乱和动物模型。 </ p> </ section> <section xml：id =“da22693-sec-0020”> <标题类型=“main”>方法</ title> >在本试点研究中，24名成人（年龄18-60岁））主要诊断Asad被随机化为12？几周的vilazodone（ n </ i>Δ=α13）或安慰剂（ n </ i>？=？11）。结果是由独立评估者和自我评估评估的结果，并用混合效果模型分析。 </ p> </ section> <section XML：ID =“DA22693-SEC-0030”> <标题类型=“main”>结果</ title> >此样品主要是女性（67％），具有可笑的精神病疾病（58％）和成人发病的分离焦虑症（62％）。第12周的回复率在组之间没有显着差异。在所有时间点，Vilazodone集团对分离焦虑症状的结构化临床面试进行了更大的改善（ P </ i>？= ?. 026）和生活质量享受和满意问卷（ p？ </ i> = ?. 011），趋势更加改善 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2017年第12期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schneier Franklin R.&option=202" target="_blank" rel="nofollow">Schneier Franklin R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Moskow Danielle M.&option=202" target="_blank" rel="nofollow">Moskow Danielle M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Choo Tse‐Hwei&option=202" target="_blank" rel="nofollow">Choo Tse‐Hwei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Galfalvy Hanga&option=202" target="_blank" rel="nofollow">Galfalvy Hanga;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Campeas Raphael&option=202" target="_blank" rel="nofollow">Campeas Raphael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sanchez‐Lacay Arturo&option=202" target="_blank" rel="nofollow">Sanchez‐Lacay Arturo;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Division of Clinical Therapeutics New York State Psychiatric InstituteNew York NY USA;</p> <p>Division of Clinical Therapeutics New York State Psychiatric InstituteNew York NY USA;</p> <p>Department of Psychiatry Columbia University Medical CenterNew York NY USA;</p> <p>Department of Psychiatry Columbia University Medical CenterNew York NY USA;</p> <p>Division of Clinical Therapeutics New York State Psychiatric InstituteNew York NY USA;</p> <p>Division of Clinical Therapeutics New York State Psychiatric InstituteNew York NY USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antidepressants&option=203" rel="nofollow">antidepressants;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anxiety/anxiety disorders&option=203" rel="nofollow">anxiety/anxiety disorders;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=clinical trials&option=203" rel="nofollow">clinical trials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pharmacotherapy&option=203" rel="nofollow">pharmacotherapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=separation anxiety&option=203" rel="nofollow">separation anxiety;</a> </p> <div class="translation"> 机译：抗抑郁药;焦虑/焦虑症;临床试验;药物治疗;分离焦虑; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a 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2021</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-hemorheology_thesis/0201288445233.html">右美托咪定对成人心脏手术后谵妄发生的影响:随机对照试验的荟萃分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=叶红&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 叶红</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈军</a> <span> <a href="/journal-cn-6013/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国血液流变学杂志 </a> </span> <span> . 2020</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_medical-innovation-china_thesis/0201272893864.html">无创通气对急性呼吸衰竭成人患者插管率及住院死亡率的影响:一项基于随机对照试验的荟萃分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姚智聪&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 姚智聪</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄礼治&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄礼治</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=荣福&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,荣福</a> <span> <a href="/journal-cn-6703/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国医学创新 </a> </span> <span> . 2019</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-38983_thesis/020222418656.html">右室非心尖部起搏与心尖部起搏对左室功能的中远期影响:随机对照试验的系统综述和meta分析</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱晴&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 朱晴</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵翠婷&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵翠婷</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马春燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,马春燕</a> <span> <a href="/conference-cn-38983/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2018海峡两岸医药卫生交流与合作会议暨第十届海峡两岸超声医学高端论坛 </a> <span> <span> . 2018</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/0203144873.html">成人胰岛细胞分离纯化及免疫抑制剂对胰岛细胞功能影响的试验研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王振&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王振</a> <span> . 2005</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112792211.html">基于LightGBM集成多个BERT模型的随机对照试验识别方法</a> <b>[P]</b> . <span> 中国专利： CN112836772A </span> <span> . 2021-05-25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120113253605.html">临床随机对照试验系统评价证据质量评分方法及其应用</a> <b>[P]</b> . <span> 中国专利： CN113299394A </span> <span> . 2021-08-24</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130422983980.html">compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b)</a> <b>[P]</b> . <span> 外国专利：  BRPI0613031A2 </span> <span> . 2012-01-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：化合物，药物组合物;该化合物在制备用于治疗肠易激综合症，治疗疼痛或疼痛综合症，治疗尿失禁，治疗抑郁症，纤维肌痛，焦虑症，恐慌症，广场恐惧症，创伤前应激障碍，烦躁不安症，月经失调的药物中的用途，注意力缺陷障碍，强迫症，社交焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，抽动秽语综合征，血管舒缩放电，可卡因成瘾，性功能障碍，人格阈障碍，纤维肌痛综合征，糖尿病性神经性疼痛，慢性疲劳综合症，害羞药物综合征，雷诺氏综合症，帕金森氏病和癫痫病，结构式（a）的化合物的制备方法和结构式（b）的化合物的制备方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130444679515.html">Use of product comprising catuama extract as an antidepressant agent and in anxiety disorders, pharmaceutical composition comprising such product for treating or preventing depression and / or anxiety disorders, method for treating or preventing depression and / or anxiety disorders using said product and use of said product for producing a pharmaceutical composition for treating or preventing depression and / or anxiety disorders</a> <b>[P]</b> . <span> 外国专利：  BR0102184A </span> <span> . 2003-02-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含catuama提取物作为抗抑郁药和在焦虑症中的产品的用途，包含该产品的用于治疗或预防抑郁症和/或焦虑症的药物组合物，使用所述产品治疗或预防抑郁症和/或焦虑症的方法以及所述产品的用途用于生产用于治疗或预防抑郁症和/或焦虑症的药物组合物 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130403071660.html">A method of obtaining a valid pathogenetically based model for preclinical trials of new anxiolytics intended for the treatment of anxiety disorders, comorbid with abscess epilepsy</a> <b>[P]</b> . <span> 外国专利：  RU2018107196A3 </span> <span> . 2019-08-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一种用于新的抗焦虑药的临床前试验的有效的基于病原学模型的方法，用于治疗焦虑症并发脓肿性癫痫 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025195323','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: 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