Comparison of microvascular perfusion evaluation among IVIM-DWI, CT perfusion imaging and histological microvessel density in rabbit liver VX2 tumors

摘要

AbstractObjectTo explore microcirculation features with intravoxel incoherent motion (IVIM) and to compare IVIM with CT perfusion imaging (CTPI) and microvessel density (MVD).Materials and methodsHepatic CTPI and IVIM were performed in 16 rabbit liver VX2 tumor models. Hepatic arterial perfusion (HAP), hepatic arterial perfusion index (HPI), Blood flow (BF), and blood volume (BV) from CTPI were measured. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*) from IVIM were measured. MVD was counted with CD34 stain. The microcirculation features with IVIM were compared with CTPI parameters and MVD.ResultsStrong linear correlations were found between D value (0.89±0.21×10?3mm2/s) and HAP (15.83±6.97ml/min/100mg) (r=0.755,P=0.001) and between f value (12.64±6.66%) and BV (9.74±5.04ml/100mg) (r=0.693,P=0.004). Moderate linear correlations were observed between ADC (1.07±0.32×10?3mm2/s) and HAP (r=0.538,P=0.039), respectively; and between D value and MVD (9.31±2.57 vessels at 400×magnification) (r=0.509,P=0.044). No correlations