Can disease progression be predicted in forearm muscle of Duchenne muscular dystrophy patients using quantitative fat-water NMRI?

摘要

Several studies in Duchenne muscular dystrophy (DMD) have shown trajectories of both functional and qNMRI outcome measures~(1-4). Here, we present longitudinal qNMRI data in forearm for up to seven years in the AFM Genethon-sponsored DMD natural history study. We wanted to investigate how well disease progression, using muscle fat fraction (FF), could be predicted using a sigmoidal model.